Primary Esophageal Mixed Sarcomatoid and Small Cell Neuroendocrine Carcinoma With Brain Metastasis: A Challenging Diagnosis on Biopsy.
Brain Neoplasms
/ secondary
Carcinoma, Neuroendocrine
/ genetics
Carcinoma, Small Cell
/ genetics
Carcinosarcoma
/ secondary
Class I Phosphatidylinositol 3-Kinases
/ genetics
Cyclin-Dependent Kinase Inhibitor p16
/ genetics
Esophageal Neoplasms
/ genetics
Female
Humans
Middle Aged
Mutation
Neoplasms, Complex and Mixed
/ genetics
brain metastasis
esophagus
mixed tumor
sarcomatoid carcinoma
small cell carcinoma
Journal
International journal of surgical pathology
ISSN: 1940-2465
Titre abrégé: Int J Surg Pathol
Pays: United States
ID NLM: 9314927
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
pubmed:
17
7
2018
medline:
14
6
2019
entrez:
17
7
2018
Statut:
ppublish
Résumé
Mixed carcinomas in the esophagus are highly uncommon neoplasms that represent a diagnostic challenge on small tissue biopsies. We present a case of a primary mixed sarcomatoid-small cell carcinoma of the esophagus that was diagnosed after repeat sampling of the lesion. The components were morphologically distinct and could be further classified by immunohistochemistry. Next-generation sequencing identified mutations in PIK3CA and CDKN2A. The small cell component morphology was also identified in brain metastasis.
Identifiants
pubmed: 30009659
doi: 10.1177/1066896918782426
doi:
Substances chimiques
CDKN2A protein, human
0
Cyclin-Dependent Kinase Inhibitor p16
0
Class I Phosphatidylinositol 3-Kinases
EC 2.7.1.137
PIK3CA protein, human
EC 2.7.1.137
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM