Postsynaptic GluR2 Involved in Amelioration of Aβ-Induced Memory Dysfunction by KAIXIN-San Through Rescuing Hippocampal LTP in Mice.

Amyloid beta-Peptides / toxicity Animals Dentate Gyrus / drug effects Drugs, Chinese Herbal / pharmacology Hippocampus / drug effects Long-Term Potentiation / drug effects Memory Disorders / drug therapy Mice, Inbred ICR Receptors, AMPA / metabolism Synapses / metabolism
KXS amyloid-β long-term potentiation memory

Journal

Rejuvenation research
ISSN: 1557-8577
Titre abrégé: Rejuvenation Res
Pays: United States
ID NLM: 101213381

Informations de publication

Date de publication:
Apr 2019
Historique:
pubmed: 17 7 2018
medline: 16 11 2019
entrez: 17 7 2018
Statut: ppublish

Résumé

Kaixin-San (KXS), a Chinese formula, was used to treat "amnesia," a senile dementia in the modern world. This formula was reported to improve behavioral performances in many animal models. This study was designed to explore how KXS has improved amyloid-β (Aβ)-induced memory dysfunction in mice. The mouse models were achieved through unilateral ventricle injection with Aβ

Identifiants

DOI: 10.1089/rej.2018.2080 PMID: 30009679
pubmed: 30009679
doi: 10.1089/rej.2018.2080
doi:

Substances chimiques

Amyloid beta-Peptides 0
Drugs, Chinese Herbal 0
Receptors, AMPA 0
kaixin 0
glutamate receptor ionotropic, AMPA 2 P6W5IXV8V9

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

131-137

Auteurs

Bo Zhang (B)

1 Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.

Yan Li (Y)

1 Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.

Jia-Wei Liu (JW)

2 Department of Organic Chemistry, School of Pharmacy, Mudanjiang Medical University, Mudanjiang, China.

Xue-Wei Liu (XW)

1 Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
3 Department of Neuropharmacology, College of Pharmacy, Qiqihar Medical University, Qiqihar, China.

Wei Wen (W)

1 Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.

Yu Cui (Y)

4 Department of Veterinary Medicine, Institute of tropical agriculture and forestry, Hainan University, Haikou, China.

Shu-Ming Huang (SM)

1 Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Postsynaptic GluR2 Involved in Amelioration of...
questionsmedicales.fr › Eucaryotes › Animaux › Postsynaptic GluR2 Involved in Amelioration of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Gyrus denté › Postsynaptic GluR2 Involved in Amelioration of...
questionsmedicales.fr › Préparations pharmaceutiques › Médicaments issus de plantes chinoises › Postsynaptic GluR2 Involved in Amelioration of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Postsynaptic GluR2 Involved in Amelioration of...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Potentialisation à long terme › Postsynaptic GluR2 Involved in Amelioration of...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Troubles de la mémoire › Postsynaptic GluR2 Involved in Amelioration of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée ICR › Postsynaptic GluR2 Involved in Amelioration of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs ionotropes du glutamate › Récepteur de l'AMPA › Postsynaptic GluR2 Involved in Amelioration of...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Postsynaptic GluR2 Involved in Amelioration of...