Electro-mechanical (dys-)function in long QT syndrome type 1.
Action Potentials
/ drug effects
Animals
Animals, Genetically Modified
Anti-Arrhythmia Agents
/ pharmacology
Biomechanical Phenomena
Disease Models, Animal
Electrocardiography
/ methods
Magnetic Resonance Imaging, Cine
Male
Myocardial Contraction
/ drug effects
Myocytes, Cardiac
/ metabolism
Piperidines
/ pharmacology
Pyridines
/ pharmacology
Rabbits
Romano-Ward Syndrome
/ diagnosis
Electro-mechanical dysfunction
Genotype differences
I(Kr)-blockade
Long QT syndrome
Tissue-phase mapping cardiac MRI
Journal
International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291
Informations de publication
Date de publication:
01 Jan 2019
01 Jan 2019
Historique:
received:
13
03
2018
revised:
18
05
2018
accepted:
06
07
2018
pubmed:
19
7
2018
medline:
25
7
2019
entrez:
19
7
2018
Statut:
ppublish
Résumé
Prolonged repolarization is the hallmark of long QT syndrome (LQTS), which is associated with subclinical mechanical dysfunction. We aimed at elucidating mechanical cardiac function in LQTS type 1 (loss of I Transgenic LQT1 and wild type (WT) rabbits (n = 12/10) were subjected to tissue phase mapping MRI, ECG, and epicardial AP recording. Protein and mRNA levels of ion channels and Ca At baseline, QT intervals were longer in LQT1 compared to WT rabbits, but baseline systolic and diastolic myocardial peak velocities were similar in LQT1 and WT. E-4031 prolonged QT more pronouncedly in LQT1. Additionally, E-4031 increased systolic and decreased diastolic peak velocities more markedly in LQT1 - unmasking systolic and diastolic LQT1-specific mechanical alterations. E-4031-induced alterations of diastolic peak velocities correlated with the extent of QT prolongation. While baseline mechanical function is normal in LQT1 despite a distinct QT prolongation, further prolongation of repolarization by I
Sections du résumé
BACKGROUND
BACKGROUND
Prolonged repolarization is the hallmark of long QT syndrome (LQTS), which is associated with subclinical mechanical dysfunction. We aimed at elucidating mechanical cardiac function in LQTS type 1 (loss of I
METHODS
METHODS
Transgenic LQT1 and wild type (WT) rabbits (n = 12/10) were subjected to tissue phase mapping MRI, ECG, and epicardial AP recording. Protein and mRNA levels of ion channels and Ca
RESULTS
RESULTS
At baseline, QT intervals were longer in LQT1 compared to WT rabbits, but baseline systolic and diastolic myocardial peak velocities were similar in LQT1 and WT. E-4031 prolonged QT more pronouncedly in LQT1. Additionally, E-4031 increased systolic and decreased diastolic peak velocities more markedly in LQT1 - unmasking systolic and diastolic LQT1-specific mechanical alterations. E-4031-induced alterations of diastolic peak velocities correlated with the extent of QT prolongation.
CONCLUSION
CONCLUSIONS
While baseline mechanical function is normal in LQT1 despite a distinct QT prolongation, further prolongation of repolarization by I
Identifiants
pubmed: 30017522
pii: S0167-5273(18)31662-0
doi: 10.1016/j.ijcard.2018.07.050
pii:
doi:
Substances chimiques
Anti-Arrhythmia Agents
0
Piperidines
0
Pyridines
0
E 4031
113558-89-7
Types de publication
Journal Article
Langues
eng
Pagination
144-151Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.