Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications.
endoplasmic reticulum
proteostasis
signalling pathway
stress
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
18
03
2018
revised:
24
06
2018
accepted:
18
07
2018
pubmed:
22
7
2018
medline:
19
7
2019
entrez:
21
7
2018
Statut:
ppublish
Résumé
The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the production and folding of approximately one-third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. Specific ER stress signalling pathways, collectively known as the unfolded protein response (UPR), are required for maintaining ER homeostasis. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. In this review, we provide a UPR signalling-centric view of ER functions, from the ER's discovery to the latest advancements in the understanding of ER and UPR biology. Our review provides a synthesis of intracellular ER signalling revolving around proteostasis and the UPR, its impact on other organelles and cellular behaviour, its multifaceted and dynamic response to stress and its role in physiology, before finally exploring the potential exploitation of this knowledge to tackle unresolved biological questions and address unmet biomedical needs. Thus, we provide an integrated and global view of existing literature on ER signalling pathways and their use for therapeutic purposes.
Identifiants
pubmed: 30027602
doi: 10.1111/febs.14608
pmc: PMC7379631
doi:
Banques de données
PDB
['5HGI', '4U6R', '4PL3', '3LJ0']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
241-278Informations de copyright
© 2018 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
Références
J Cell Sci. 2011 Jul 1;124(Pt 13):2143-52
pubmed: 21628424
J Biol Chem. 2004 May 7;279(19):20108-17
pubmed: 14978030
Mol Cell Biol. 1998 Dec;18(12):7499-509
pubmed: 9819435
Cell Rep. 2018 Jun 5;23(10):3006-3020
pubmed: 29874586
Genes Dev. 2000 Nov 1;14(21):2725-36
pubmed: 11069889
Cell. 2007 Jun 29;129(7):1337-49
pubmed: 17604722
Antioxid Redox Signal. 2014 Jul 20;21(3):396-413
pubmed: 24702237
Exp Cell Res. 2001 Jul 15;267(2):193-204
pubmed: 11426938
Science. 2004 Oct 15;306(5695):457-61
pubmed: 15486293
Diabetes. 2007 Apr;56(4):901-11
pubmed: 17395738
Oncotarget. 2017 Mar 28;8(13):20974-20987
pubmed: 28423496
Mol Biol Cell. 2004 Feb;15(2):908-21
pubmed: 14668485
Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70
pubmed: 2138778
Mol Cell. 2018 Jan 18;69(2):238-252.e7
pubmed: 29351844
Tufts Folia Med. 1962 Oct-Dec;8:134-43
pubmed: 14034742
Pharmacol Ther. 2012 Jun;134(3):306-16
pubmed: 22387231
Nat Commun. 2014 Aug 28;5:4202
pubmed: 25164867
J Cell Biol. 2009 Aug 10;186(3):323-31
pubmed: 19651891
Eur J Cell Biol. 2016 Mar-May;95(3-5):115-23
pubmed: 26905505
Science. 2005 Feb 11;307(5711):935-9
pubmed: 15705855
Nat Chem Biol. 2012 Dec;8(12):982-9
pubmed: 23086298
J Clin Invest. 2001 Mar;107(5):585-93
pubmed: 11238559
Biosci Rep. 2002 Jun-Aug;22(3-4):407-20
pubmed: 12516782
J Biol Chem. 2002 Sep 13;277(37):34287-94
pubmed: 12097332
EMBO J. 2014 Nov 3;33(21):2492-506
pubmed: 25239945
Semin Liver Dis. 2007 Nov;27(4):367-77
pubmed: 17979073
ACS Med Chem Lett. 2013 Aug 12;4(10):964-8
pubmed: 24900593
Nucleic Acids Res. 2010 Oct;38(18):6265-73
pubmed: 20507909
Crit Rev Biochem Mol Biol. 2010 Jun;45(3):185-98
pubmed: 20482385
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5886-E5895
pubmed: 27651490
Cell Metab. 2014 Jul 1;20(1):73-84
pubmed: 24836559
Cell. 2000 Apr 28;101(3):249-58
pubmed: 10847680
Cell. 2009 Aug 7;138(3):562-75
pubmed: 19665977
Int J Biochem Cell Biol. 2015 Aug;65:230-8
pubmed: 26065400
Mol Cell. 2010 Apr 23;38(2):291-304
pubmed: 20417606
Nat Cell Biol. 2005 Aug;7(8):766-72
pubmed: 16056268
Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E869-78
pubmed: 22315414
Endocrinology. 2008 Aug;149(8):3832-41
pubmed: 18450959
Mol Biosyst. 2013 Oct;9(10):2408-16
pubmed: 23884086
Circ Res. 2006 May 12;98(9):1186-93
pubmed: 16601230
Science. 2006 Jul 7;313(5783):104-7
pubmed: 16825573
Genes Dev. 2005 Mar 1;19(5):553-69
pubmed: 15706034
Cell Death Differ. 2017 Jun;24(6):1100-1110
pubmed: 28452996
World J Gastroenterol. 2017 Feb 14;23(6):986-998
pubmed: 28246472
Trends Cell Biol. 2009 Feb;19(2):81-8
pubmed: 19144519
J Cell Mol Med. 2012 Jan;16(1):142-51
pubmed: 21388518
Science. 2008 Jun 13;320(5882):1492-6
pubmed: 18556558
J Biol Chem. 1993 Aug 25;268(24):18226-33
pubmed: 8349698
Nucleic Acids Res. 2010 Jan;38(3):764-77
pubmed: 19934253
Science. 2004 Jun 4;304(5676):1500-2
pubmed: 15131264
Biochem Biophys Res Commun. 2017 Jun 17;488(1):40-45
pubmed: 28476623
Nat Rev Drug Discov. 2011 Apr;10(4):292-306
pubmed: 21455238
New Phytol. 2016 Jun;210(4):1259-68
pubmed: 26831622
Curr Opin Cell Biol. 2006 Aug;18(4):358-64
pubmed: 16806883
Science. 2000 Jan 28;287(5453):664-6
pubmed: 10650002
EBioMedicine. 2015 May 09;2(6):482-3
pubmed: 26288807
Int J Mol Sci. 2012 Dec 24;14(1):434-56
pubmed: 23263672
Mol Cell Biol. 2014 May;34(9):1695-706
pubmed: 24591649
ACS Med Chem Lett. 2014 Sep 24;6(1):68-72
pubmed: 25589933
Nat Cell Biol. 2009 Oct;11(10):1205-11
pubmed: 19767743
Elife. 2015 Apr 15;4:e07314
pubmed: 25875391
Int J Mol Sci. 2015 Dec 02;16(12):28635-46
pubmed: 26633383
J Biol Chem. 2004 Oct 29;279(44):45495-502
pubmed: 15322075
Cell. 2014 Nov 20;159(5):1027-1041
pubmed: 25416943
Am J Hum Genet. 2004 Nov;75(5):822-31
pubmed: 15372378
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Clin Exp Reprod Med. 2015 Mar;42(1):1-7
pubmed: 25874167
Nature. 2011 May 26;473(7348):528-31
pubmed: 21532591
J Biol Chem. 2013 Aug 30;288(35):25350-61
pubmed: 23888053
Cell. 2007 Dec 14;131(6):1047-58
pubmed: 18083096
Mol Cell. 2009 Mar 27;33(6):679-91
pubmed: 19328063
J Biol Chem. 2011 Sep 2;286(35):30253-7
pubmed: 21757685
Nat Rev Mol Cell Biol. 2012 Jan 18;13(2):89-102
pubmed: 22251901
Endocr Regul. 2016 Apr;50(2):43-54
pubmed: 27560636
J Biol Chem. 1980 Feb 10;255(3):1189-93
pubmed: 6153180
Immunopharmacol Immunotoxicol. 2008;30(2):257-70
pubmed: 18569083
J Biol Chem. 2006 Mar 17;281(11):7260-70
pubmed: 16407291
PLoS One. 2011;6(10):e25545
pubmed: 21998667
Annu Rev Biochem. 2011;80:71-99
pubmed: 21495850
J Biol Chem. 2011 Apr 8;286(14):12743-55
pubmed: 21303903
Cell Metab. 2017 Jul 5;26(1):212-229.e12
pubmed: 28683288
Mol Biol Cell. 2014 May;25(9):1411-20
pubmed: 24623724
Diabetologia. 2007 May;50(5):1006-14
pubmed: 17333111
J Biol Chem. 2011 Apr 1;286(13):10939-49
pubmed: 21285359
FASEB J. 2011 Sep;25(9):3115-29
pubmed: 21680894
Mol Cell. 2000 Dec;6(6):1355-64
pubmed: 11163209
PLoS One. 2014 Jul 31;9(7):e103882
pubmed: 25078779
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5713-8
pubmed: 23509268
J Biol Chem. 2012 Mar 9;287(11):8144-53
pubmed: 22262831
Genes Dev. 2000 Jan 15;14(2):152-7
pubmed: 10652269
Front Genet. 2013 Dec 02;4:256
pubmed: 24348511
Cell. 1994 Jun 17;77(6):895-907
pubmed: 8004676
Am J Physiol Cell Physiol. 2015 Mar 15;308(6):C415-25
pubmed: 25540175
J Cell Biol. 2004 Feb 2;164(3):341-6
pubmed: 14757749
Science. 2006 Aug 25;313(5790):1137-40
pubmed: 16931765
J Biol Chem. 2003 Aug 15;278(33):31024-32
pubmed: 12782636
Immunol Rev. 2017 Nov;280(1):126-148
pubmed: 29027218
Nat Cell Biol. 2013 May;15(5):481-90
pubmed: 23624402
Cell. 2017 Dec 14;171(7):1625-1637.e13
pubmed: 29198525
F1000Res. 2017 Oct 27;6:1897
pubmed: 29152224
Nat Med. 2011 Sep 04;17(10):1251-60
pubmed: 21892182
Brain Res. 2013 Jun 26;1519:1-8
pubmed: 23648361
J Biochem. 2011 May;149(5):507-18
pubmed: 21454302
Cell Death Dis. 2015 Jan 15;6:e1591
pubmed: 25590801
Cold Spring Harb Symp Quant Biol. 2011;76:355-67
pubmed: 22123850
FEBS Lett. 2008 Mar 5;582(5):656-60
pubmed: 18242182
EMBO Mol Med. 2018 Mar;10(3):
pubmed: 29311133
Biol Reprod. 2009 May;80(5):944-53
pubmed: 19129515
Dev Cell. 2003 Feb;4(2):265-71
pubmed: 12586069
Cell Metab. 2008 Jun;7(6):520-32
pubmed: 18522833
Mol Cell Biol. 2012 Dec;32(24):5129-39
pubmed: 23071091
Neurobiol Dis. 2008 Jun;30(3):400-7
pubmed: 18440237
Trends Biochem Sci. 2014 May;39(5):245-54
pubmed: 24657016
Cell Signal. 2016 Nov;28(11):1789-805
pubmed: 27555288
Neurotoxicology. 2014 Mar;41:102-11
pubmed: 24486958
Biochemistry. 1964 Apr;3:480-2
pubmed: 14192894
Cell. 2016 Nov 3;167(4):1052-1066.e18
pubmed: 27814504
Mol Cell Biol. 2001 Oct;21(20):6841-50
pubmed: 11564868
Mol Cell Biol. 2003 Nov;23(21):7448-59
pubmed: 14559994
J Biol Chem. 2003 Sep 12;278(37):34864-73
pubmed: 12840028
Cell Death Differ. 2009 Jun;16(6):847-57
pubmed: 19247368
Biochem J. 2011 Sep 1;438(2):283-9
pubmed: 21644928
J Cell Physiol. 2013 Sep;228(9):1802-18
pubmed: 23629871
J Bioenerg Biomembr. 2016 Apr;48(2):153-68
pubmed: 25620271
Cell Metab. 2012 Oct 3;16(4):487-99
pubmed: 23040070
Pancreas. 2013 Jan;42(1):92-101
pubmed: 22889983
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4679-83
pubmed: 8506317
Sci Rep. 2016 Sep 16;6:33353
pubmed: 27634301
Mol Cell. 2003 Mar;11(3):619-33
pubmed: 12667446
Mol Ther. 2012 Feb;20(2):432-42
pubmed: 21934655
Cell. 1996 Nov 1;87(3):391-404
pubmed: 8898193
J Biomol Screen. 2015 Dec;20(10):1232-45
pubmed: 26265713
Cell Signal. 2012 Feb;24(2):484-92
pubmed: 21983012
Biochem Soc Trans. 2016 Apr 15;44(2):493-8
pubmed: 27068960
PLoS Genet. 2013;9(8):e1003529
pubmed: 23950723
Nature. 2014 Jun 12;510(7504):268-72
pubmed: 24776803
J Cell Physiol. 2015 Jul;230(7):1661-76
pubmed: 25546329
Immunol Rev. 2003 Aug;194:29-38
pubmed: 12846805
Am J Physiol Cell Physiol. 2017 Sep 1;313(3):C243-C254
pubmed: 28637678
PLoS One. 2015 Apr 30;10(4):e0123578
pubmed: 25928708
Nat Rev Immunol. 2017 Feb;17(2):97-111
pubmed: 27748397
J Cell Sci. 2001 Mar;114(Pt 5):867-74
pubmed: 11181170
Mol Cell Biochem. 2012 May;364(1-2):115-29
pubmed: 22246806
Science. 2013 May 10;340(6133):730-4
pubmed: 23661758
Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16348-53
pubmed: 22988091
Int J Mol Med. 2014 Sep;34(3):772-81
pubmed: 24970676
Science. 2015 May 29;348(6238):1027-30
pubmed: 25858979
Int Rev Cell Mol Biol. 2015;316:227-65
pubmed: 25805126
Mol Cell. 2014 Sep 4;55(5):758-70
pubmed: 25087875
J Cell Physiol. 2005 Oct;205(1):47-57
pubmed: 15887240
Blood. 2017 Apr 27;129(17):2420-2428
pubmed: 28167662
PLoS One. 2008 Feb 20;3(2):e1648
pubmed: 18286202
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62
pubmed: 19805353
Int J Mol Sci. 2016 May 25;17(6):
pubmed: 27231901
Cell Death Dis. 2015 Mar 05;6:e1672
pubmed: 25741597
J Clin Invest. 2002 Feb;109(4):525-32
pubmed: 11854325
J Biol Chem. 1988 Apr 25;263(12):5526-33
pubmed: 3356695
Elife. 2012 Oct 15;1:e00048
pubmed: 23066505
Int J Dev Neurosci. 2007 Nov;25(7):455-63
pubmed: 17913437
J Cell Sci. 2015 Dec 1;128(23):4263-72
pubmed: 26567219
Cell Stress Chaperones. 2013 May;18(3):307-19
pubmed: 23160805
Mol Cell Biol. 1997 Sep;17(9):4957-66
pubmed: 9271374
FEBS Lett. 2007 May 1;581(9):1769-74
pubmed: 17418825
Sci Signal. 2016 Feb 16;9(415):ra17
pubmed: 26884599
Blood. 2012 Jun 14;119(24):5772-81
pubmed: 22538852
Elife. 2017 Sep 27;6:
pubmed: 28952924
J Cancer. 2017 Jul 2;8(10):1826-1832
pubmed: 28819380
Nat Immunol. 2015 Aug;16(8):829-37
pubmed: 26147683
Cancer Lett. 2016 Dec 28;383(2):204-211
pubmed: 27697610
Proc Natl Acad Sci U S A. 1991 May 15;88(10):4309-12
pubmed: 1903538
J Neurosci. 2014 Mar 12;34(11):3810-20
pubmed: 24623760
Front Oncol. 2015 Jan 06;4:379
pubmed: 25610811
J Neurosci. 2012 Mar 7;32(10):3306-20
pubmed: 22399753
J Cell Biol. 2004 Oct 11;167(1):35-41
pubmed: 15466483
EMBO J. 1998 Oct 1;17(19):5708-17
pubmed: 9755171
PLoS One. 2013 Oct 18;8(10):e76941
pubmed: 24204710
J Immunol. 2014 Apr 15;192(8):3475-87
pubmed: 24623133
J Biol Chem. 2011 Jul 29;286(30):26319-26
pubmed: 21636578
Arthritis Rheum. 2006 Mar;54(3):854-63
pubmed: 16508967
Nat Cell Biol. 2001 Feb;3(2):158-64
pubmed: 11175748
Pain. 2016 Jan;157(1):70-9
pubmed: 26230740
Nat Cell Biol. 2003 Sep;5(9):781-92
pubmed: 12907943
Life Sci. 2017 Jul 15;181:17-22
pubmed: 28465244
Cell. 2001 Dec 28;107(7):881-91
pubmed: 11779464
Free Radic Biol Med. 2000 Aug;29(3-4):222-30
pubmed: 11035250
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2809-14
pubmed: 16478805
Nephrology (Carlton). 2013 Oct;18(10):682-9
pubmed: 23841795
Cell Metab. 2012 Oct 3;16(4):473-86
pubmed: 23040069
Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11041-8
pubmed: 10500120
Biochem Biophys Res Commun. 1979 Feb 28;86(4):1206-13
pubmed: 435320
Int J Mol Sci. 2013 Mar 21;14(3):6454-66
pubmed: 23519110
Mol Cell Biol. 2014 May;34(10):1839-49
pubmed: 24636989
Nephron Exp Nephrol. 2014;126(3):127-40
pubmed: 24863135
Diabetes. 2002 Dec;51 Suppl 3:S455-61
pubmed: 12475790
Mol Biol Rep. 2012 Apr;39(4):3987-93
pubmed: 21779805
Mol Cell. 2000 Nov;6(5):1099-108
pubmed: 11106749
Antioxid Redox Signal. 2007 Dec;9(12):2277-93
pubmed: 17979528
Clin Cancer Res. 2017 May 15;23(10):2556-2564
pubmed: 27815359
EMBO J. 2005 Dec 21;24(24):4368-80
pubmed: 16362047
Cell. 1983 Feb;32(2):537-46
pubmed: 6297798
Cell Metab. 2009 Jun;9(6):556-64
pubmed: 19490910
J Biol Chem. 2009 Mar 13;284(11):6661-73
pubmed: 19131336
J Cell Biol. 2015 Aug 17;210(4):541-51
pubmed: 26283797
Circ Res. 2018 May 25;122(11):1545-1554
pubmed: 29669712
J Biol Chem. 1987 Jan 25;262(3):1206-12
pubmed: 2948954
Cell. 2014 Jul 31;158(3):534-48
pubmed: 25018104
J Cell Sci. 2014 Sep 1;127(Pt 17):3649-58
pubmed: 25107370
Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2762-E2771
pubmed: 29507230
Mol Cell. 2012 Jun 8;46(5):674-90
pubmed: 22681889
Curr Med Chem. 2011;18(13):2016-24
pubmed: 21517773
Biochem J. 1979 Oct 15;184(1):113-23
pubmed: 534512
Elife. 2018 Jan 05;7:
pubmed: 29303481
J Cell Mol Med. 2014 Jan;18(1):80-90
pubmed: 24373582
EMBO J. 2013 Aug 28;32(17):2348-61
pubmed: 23921556
Int J Hyperthermia. 2005 Dec;21(8):681-7
pubmed: 16338849
Cell. 2010 Mar 5;140(5):744-52
pubmed: 20211142
J Biol Chem. 2015 Jan 2;290(1):577-89
pubmed: 25398881
Nat Commun. 2014 Mar 27;5:3528
pubmed: 24670948
Int J Obes (Lond). 2012 Sep;36(9):1248-51
pubmed: 22124452
Int J Mol Sci. 2016 Mar 02;17(3):327
pubmed: 26950115
Nat Cell Biol. 2000 Jun;2(6):326-32
pubmed: 10854322
J Biol Chem. 2004 Jun 25;279(26):26846-57
pubmed: 15096521
Cancer Discov. 2014 Jun;4(6):702-15
pubmed: 24705811
Eur J Neurosci. 2016 Mar;43(5):640-52
pubmed: 26750440
Antioxid Redox Signal. 2015 Apr 20;22(12):995-1019
pubmed: 25557408
Cell Death Dis. 2015 Jan 08;6:e1587
pubmed: 25569104
Chem Soc Rev. 2009 Dec;38(12):3289-300
pubmed: 20449049
Elife. 2016 Jul 20;5:
pubmed: 27435962
Science. 2015 Apr 10;348(6231):239-42
pubmed: 25859045
J Biol Chem. 2002 Dec 6;277(49):47358-65
pubmed: 12351637
Mech Dev. 2015 Aug;137:33-44
pubmed: 25892297
Neurobiol Dis. 2014 Nov;71:317-24
pubmed: 25134731
Trends Cell Biol. 2012 May;22(5):274-82
pubmed: 22444729
Cell. 2005 Sep 23;122(6):927-39
pubmed: 16179260
J Am Soc Nephrol. 2016 Mar;27(3):863-76
pubmed: 26195817
EMBO J. 2017 May 15;36(10):1412-1433
pubmed: 28377464
J Biol Chem. 1975 Dec 10;250(23):9083-9
pubmed: 1194278
Trends Biochem Sci. 2010 Feb;35(2):74-82
pubmed: 19853458
N Engl J Med. 2014 Jan 30;370(5):455-65
pubmed: 24476434
J Exp Med. 1954 Dec 1;100(6):641-56
pubmed: 13211920
Cell. 2010 Apr 16;141(2):231-42
pubmed: 20403321
J Exp Med. 2009 Sep 28;206(10):2151-9
pubmed: 19752183
Mol Cell Biol. 2017 May 2;37(10):
pubmed: 28242652
Oncogene. 2015 Oct;34(43):5418-26
pubmed: 25684138
Dev Cell. 2002 Jul;3(1):99-111
pubmed: 12110171
Cancer Res. 2013 Mar 15;73(6):1993-2002
pubmed: 23333938
Semin Cell Dev Biol. 2010 Jul;21(5):526-32
pubmed: 20026414
Mol Cell Biol. 1989 Oct;9(10):4196-203
pubmed: 2573827
Chembiochem. 2016 May 3;17(9):843-51
pubmed: 26792008
Cell. 1997 Sep 19;90(6):1031-9
pubmed: 9323131
Cell Metab. 2018 Apr 3;27(4):828-842.e7
pubmed: 29551590
Sci Rep. 2017 Feb 08;7:42162
pubmed: 28176833
Dev Cell. 2007 Sep;13(3):365-76
pubmed: 17765680
Biochem J. 1999 Apr 1;339 ( Pt 1):135-41
pubmed: 10085237
Genes Dev. 2004 Dec 15;18(24):3066-77
pubmed: 15601821
Wellcome Open Res. 2017 Oct 9;2:36
pubmed: 29062910
SLAS Discov. 2017 Aug;22(7):787-800
pubmed: 28453376
J Biol Chem. 2011 Sep 2;286(35):30859-66
pubmed: 21757700
Diabetes. 2013 Jul;62(7):2439-49
pubmed: 23493568
Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15040-4
pubmed: 17855560
Nucleic Acids Res. 1994 Dec 11;22(24):5279-88
pubmed: 7816617
Sci Rep. 2015 Nov 12;5:16455
pubmed: 26558437
Cell. 2008 Sep 5;134(5):743-56
pubmed: 18775308
Biochem Biophys Res Commun. 2016 Jan 29;470(1):75-81
pubmed: 26742428
Cell Stress Chaperones. 2018 Sep;23(5):897-912
pubmed: 29725981
Biochim Biophys Acta Mol Cell Res. 2017 Apr;1864(4):655-665
pubmed: 28093214
Methods Enzymol. 2011;490:71-92
pubmed: 21266244
Sci Transl Med. 2013 Oct 9;5(206):206ra138
pubmed: 24107777
Blood Cancer J. 2012 Jul;2(7):e79
pubmed: 22852048
Cell Death Differ. 2007 Sep;14(9):1576-82
pubmed: 17612585
Gastroenterology. 2010 Dec;139(6):2038-49
pubmed: 20816838
Anticancer Res. 2009 Jun;29(6):2195-204
pubmed: 19528481
Cell. 2011 Feb 4;144(3):389-401
pubmed: 21295699
J Biochem. 2009 Dec;146(6):743-50
pubmed: 19861400
Int J Mol Med. 2017 Jul;40(1):101-111
pubmed: 28498443
Nat Commun. 2014 Apr 07;5:3554
pubmed: 24704861
Autophagy. 2010 Feb;6(2):301-3
pubmed: 20104025
Cell Res. 2011 Nov;21(11):1619-33
pubmed: 21467995
Arch Biochem Biophys. 2010 Oct 15;502(2):137-43
pubmed: 20692228
Exp Cell Res. 2008 Aug 1;314(13):2454-67
pubmed: 18561914
Cancer Immunol Immunother. 2003 Apr;52(4):226-34
pubmed: 12669247
Tumour Biol. 2015 Mar;36(3):1859-69
pubmed: 25431258
Cell Death Differ. 2006 Mar;13(3):374-84
pubmed: 16397578
PLoS Genet. 2011 Nov;7(11):e1002391
pubmed: 22125500
Cell Mol Biol Lett. 2013 Dec;18(4):555-78
pubmed: 24092331
Blood. 2009 Oct 29;114(18):3880-9
pubmed: 19654406
Elife. 2016 Jul 20;5:
pubmed: 27435960
Nat Med. 2011 Mar;17(3):356-65
pubmed: 21317886
Mol Biol Cell. 2001 Jun;12(6):1711-23
pubmed: 11408579
Biochem Biophys Res Commun. 2010 Jul 9;397(4):735-9
pubmed: 20541525
J Clin Invest. 2013 Jan;123(1):455-68
pubmed: 23257357
Mol Cell. 2009 Nov 13;36(3):487-99
pubmed: 19917256
J Am Soc Nephrol. 2016 Oct;27(10):2974-2982
pubmed: 26940092
Int Immunol. 2004 Apr;16(4):597-605
pubmed: 15039390
Mediators Inflamm. 2015;2015:417281
pubmed: 26491226
Nature. 1999 Jan 21;397(6716):271-4
pubmed: 9930704
J Cell Biol. 2001 May 28;153(5):1011-22
pubmed: 11381086
Cancer Discov. 2015 Jun;5(6):586-97
pubmed: 25977222
Trends Biochem Sci. 1998 Jan;23(1):10-4
pubmed: 9478128
Sci Signal. 2017 Jun 06;10(482):
pubmed: 28588081
Proc Natl Acad Sci U S A. 2011 May 24;108(21):8885-90
pubmed: 21555585
Mol Cancer Res. 2015 Oct;13(10):1377-88
pubmed: 26130148
Semin Cell Dev Biol. 1999 Oct;10(5):495-505
pubmed: 10597632
Science. 1990 Mar 30;247(4950):1581-4
pubmed: 2321018
J Biol Chem. 2001 Jun 29;276(26):23681-8
pubmed: 11323415
Mucosal Immunol. 2013 May;6(3):639-54
pubmed: 23168839
Elife. 2015 Feb 26;4:
pubmed: 25719440
Anat Sci Int. 2014 Jan;89(1):11-20
pubmed: 24242870
J Biol Chem. 2009 Jan 16;284(3):1593-603
pubmed: 19004820
PLoS One. 2013;8(1):e53431
pubmed: 23301071
Top Curr Chem. 2013;328:1-34
pubmed: 21630134
Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H871-H880
pubmed: 27496879
Proc Natl Acad Sci U S A. 1979 Feb;76(2):791-5
pubmed: 218220
Nature. 2014 Apr 3;508(7494):103-107
pubmed: 24670641
J Biol Chem. 2011 Feb 11;286(6):4809-18
pubmed: 21135100
Brain Res. 2015 Nov 19;1627:12-20
pubmed: 26390938
Biochim Biophys Acta. 2013 Dec;1833(12):3460-3470
pubmed: 23850759
Mol Cell. 2009 Apr 24;34(2):191-200
pubmed: 19394296
Biochem Biophys Res Commun. 1999 Aug 2;261(2):350-6
pubmed: 10425189
Neuroscience. 2015 Dec 17;311:362-73
pubmed: 26523978
Nat Neurosci. 2009 May;12(5):627-36
pubmed: 19330001
J Med Chem. 2012 Aug 23;55(16):7193-207
pubmed: 22827572
Genes Dev. 1989 Dec;3(12B):2083-90
pubmed: 2516827
Curr Opin Cell Biol. 2011 Aug;23(4):458-63
pubmed: 21555211
Proc Natl Acad Sci U S A. 1988 Dec;85(23):8800-4
pubmed: 3194391
Breast Cancer Res. 2007;9(6):R80
pubmed: 18300387
Nature. 2001 Jul 19;412(6844):300-7
pubmed: 11460154
FEBS Lett. 1993 Nov 15;334(2):149-52
pubmed: 7693513
Mol Cell Biol. 2006 Dec;26(24):9220-31
pubmed: 17030611
Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29
pubmed: 17565364
Cell Stress Chaperones. 2003 Fall;8(3):242-8
pubmed: 14984057
Cell. 1996 Nov 1;87(3):405-13
pubmed: 8898194
J Biol Chem. 1992 Apr 5;267(10):7128-33
pubmed: 1551919
J Immunol Res. 2014;2014:140728
pubmed: 25762501
Gene Expr. 2010;15(1):13-25
pubmed: 21061914
Physiol Rev. 2007 Oct;87(4):1377-408
pubmed: 17928587
Cell Death Differ. 2019 Mar;26(3):487-501
pubmed: 29795335
Mol Cell Biol. 2006 Aug;26(15):5688-97
pubmed: 16847323
J Biol Chem. 2010 Dec 17;285(51):40266-81
pubmed: 20940299
Cell Metab. 2006 Sep;4(3):245-54
pubmed: 16950141
J Cell Biol. 2017 Jul 3;216(7):2027-2045
pubmed: 28566324
J Antibiot (Tokyo). 2008 May;61(5):312-7
pubmed: 18653997
Nature. 2002 Jan 3;415(6867):92-6
pubmed: 11780124
Elife. 2016 Jul 20;5:
pubmed: 27435961
Nucleic Acids Res. 2003 Sep 15;31(18):5266-74
pubmed: 12954762
Science. 2011 Feb 4;331(6017):586-9
pubmed: 21233347
Oncotarget. 2016 Aug 16;7(33):54010-54027
pubmed: 27304053
J Biol Chem. 2011 Sep 2;286(35):30972-80
pubmed: 21757695
Nat Rev Cancer. 2014 Jul;14(7):455-67
pubmed: 24957944
Blood. 2011 Jan 27;117(4):1311-4
pubmed: 21081713
Endocrinology. 2014 Dec;155(12):4905-14
pubmed: 25203138
J Lipid Res. 2009 Apr;50 Suppl:S311-6
pubmed: 18952570
J Lipid Res. 2008 Nov;49(11):2283-301
pubmed: 18757836
J Mol Cell Biol. 2016 Apr;8(2):144-56
pubmed: 26711306
Mol Cell. 2000 May;5(5):897-904
pubmed: 10882126
J Lipid Res. 2010 Jul;51(7):1918-28
pubmed: 20237389
ACS Chem Biol. 2016 Aug 19;11(8):2195-205
pubmed: 27227314
Cell Death Differ. 2018 Feb;25(2):255-267
pubmed: 28984870
Cell Signal. 2015 Jan;27(1):82-9
pubmed: 25280941
Genes Dev. 1998 Jun 15;12(12):1812-24
pubmed: 9637683
Genet Med. 2014 Oct;16(10):751-8
pubmed: 24651605
Cell Death Differ. 2012 Nov;19(11):1880-91
pubmed: 22705852
Trends Endocrinol Metab. 2017 Nov;28(11):794-806
pubmed: 28797581
Mol Cell. 2001 Jun;7(6):1153-63
pubmed: 11430819
J Clin Invest. 2008 Jun;118(6):2148-56
pubmed: 18451997
Rheumatology (Oxford). 2016 Nov;55(11):1993-2000
pubmed: 27498355
J Exp Med. 1945 Mar 1;81(3):233-46
pubmed: 19871454
Cell Metab. 2008 May;7(5):445-55
pubmed: 18460335
Oncogene. 2017 Oct 5;36(40):5593-5608
pubmed: 28553953
Blood. 2006 May 15;107(10):4003-10
pubmed: 16469868
EMBO J. 1990 Aug;9(8):2537-42
pubmed: 2196176
Nat Cell Biol. 2005 Feb;7(2):186-94
pubmed: 15665855
Cell. 2006 Aug 11;126(3):435-9
pubmed: 16901774
J Am Chem Soc. 2013 Feb 20;135(7):2497-500
pubmed: 23379904
J Cell Biol. 2009 Sep 21;186(6):783-92
pubmed: 19752026
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2788-93
pubmed: 14973195