Nephron progenitor cell commitment: Striking the right balance.
Differentiation
Nephrogenesis
Nephron progenitor cell (NPC)
Self-renewal
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
10
12
2017
revised:
29
06
2018
accepted:
16
07
2018
pubmed:
22
7
2018
medline:
28
4
2020
entrez:
22
7
2018
Statut:
ppublish
Résumé
The filtering component of the kidney, the nephron, arises from a single progenitor population. These nephron progenitor cells (NPCs) both self-renew and differentiate throughout the course of kidney development ensuring sufficient nephron endowment. An appropriate balance of these processes must be struck as deficiencies in nephron numbers are associated with hypertension and kidney disease. This review will discuss the mechanisms and molecules supporting NPC maintenance and differentiation. A focus on recent work will highlight new molecular insights into NPC regulation and their dynamic behavior in both space and time.
Identifiants
pubmed: 30030141
pii: S1084-9521(17)30421-4
doi: 10.1016/j.semcdb.2018.07.017
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
94-103Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.