The 3D genome: From fundamental principles to disease and cancer.
3D genome
Cancer
Chromosomal rearrangement
Epigenetics
GWAS
Hi-C
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
14
05
2018
accepted:
03
07
2018
pubmed:
22
7
2018
medline:
16
4
2020
entrez:
22
7
2018
Statut:
ppublish
Résumé
In higher eukaryotes, the three-dimensional (3D) organization of the genome is intimately related to numerous key biological functions including gene expression, DNA repair and DNA replication regulations. Alteration of this 3D organization is detrimental to the organism and can give rise to a broad range of diseases such as cancers. Here, we review recent advances in the field. We first describe how the genome is packed in 3D to form chromosome territories, compartments and domains. We also give an overview of the recent techniques that allow to map the genome in 3D up to the kilobase resolution. We then discuss potential mechanisms by which genome misfolding can affect proper gene expression by distal enhancers, and how the 3D genome influences the formation of genomic rearrangements.
Identifiants
pubmed: 30030142
pii: S1084-9521(17)30590-6
doi: 10.1016/j.semcdb.2018.07.002
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
128-137Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.