Modeling three-dimensional genomic organization in evolution and pathogenesis.
Comparative genomics
Computational models
Disease-causing mutations
Gene expression
Three-dimensional genomic organization
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
28
03
2018
accepted:
08
07
2018
pubmed:
22
7
2018
medline:
16
4
2020
entrez:
22
7
2018
Statut:
ppublish
Résumé
The regulation of gene expression is mediated via the complex three-dimensional (3D) conformation of the genetic material and its interactions with various intracellular factors. Various experimental and computational approaches have been developed in recent years for understating the relation between the 3D conformation of the genome and the phenotypes of cells in normal condition and diseases. In this review, we will discuss novel approaches for analyzing and modeling the 3D genomic conformation, focusing on deciphering disease-causing mutations that affect gene expression. We conclude that as this is a very challenging mission, an important direction should involve the comparative analysis of various 3D models from various organisms or cells.
Identifiants
pubmed: 30030143
pii: S1084-9521(17)30597-9
doi: 10.1016/j.semcdb.2018.07.008
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
78-93Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.