Regulation of apoptotic and inflammatory signaling pathways in hepatocellular carcinoma via Caesalpinia gilliesii galactomannan.
Animals
Apoptosis
/ drug effects
Caesalpinia
/ chemistry
Carcinoma, Hepatocellular
/ drug therapy
Cell Proliferation
Galactose
/ analogs & derivatives
Humans
Inflammation
/ drug therapy
Liver
/ drug effects
Liver Neoplasms
/ drug therapy
Male
Mannans
/ pharmacology
Plant Extracts
/ pharmacology
Rats
Rats, Wistar
Tumor Cells, Cultured
C-fos
Caesalpinia gilliesii
GSK-3β
Galactomannan
HepG2
Hepatocellular carcinoma
NF-κB
TNF-α
Journal
Molecular and cellular biochemistry
ISSN: 1573-4919
Titre abrégé: Mol Cell Biochem
Pays: Netherlands
ID NLM: 0364456
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
14
02
2018
accepted:
13
07
2018
pubmed:
22
7
2018
medline:
9
3
2019
entrez:
22
7
2018
Statut:
ppublish
Résumé
A polysaccharide characterized as galactomannan (GMann) with a molecular weight of 117.76 kDa was isolated from the aqueous extract of Caesalpinia gilliesii (C. gilliesii) seeds then assessed for antiproliferative potential against human hepatocellular carcinoma cell line (HepG2). Further, HCC was induced in Wister albino rats by Diethylnitrosamine (DEN) ip injection (200 mg/kg bw), and CCl4 orally (2 ml/kg bw) for two months then subjected to GMann orally treatment (2 mg/kg bw) for one month. In results, isolated GMann is constituted of sugars (89.99 ± 2.3%), moisture (6.89 ± 0.45%), ash (0.06 ± 0.2%), and protein (2.81%) and composed mainly of mannose and galactose in ratio M/G 3.79. In vitro study, data revealed a concentration-dependent potency of GMann to induce cell death of HepG2 cells with IC
Identifiants
pubmed: 30030776
doi: 10.1007/s11010-018-3404-y
pii: 10.1007/s11010-018-3404-y
doi:
Substances chimiques
Mannans
0
Plant Extracts
0
galactomannan
11078-30-1
Galactose
X2RN3Q8DNE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173-184Subventions
Organisme : Science and Technology Development Fund
ID : 5510
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