Distinct disruptions in Land's cycle remodeling of glycerophosphocholines in murine cortex mark symptomatic onset and progression in two Alzheimer's disease mouse models.

Alzheimer Disease / metabolism Amyloid beta-Protein Precursor / toxicity Animals Cerebral Cortex / metabolism Disease Models, Animal Disease Progression Humans Mice Phosphatidylcholines / metabolism
Alzheimer's disease glycerophosphocholine hypoxia lipidomics phospholipase A2 platelet-activating factor

Journal

Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R

Informations de publication

Date de publication:
05 2019
Historique:
received: 22 03 2018
revised: 04 07 2018
accepted: 20 07 2018
pubmed: 25 7 2018
medline: 19 3 2020
entrez: 25 7 2018
Statut: ppublish

Résumé

Changes in glycerophosphocholine metabolism are observed in Alzheimer's disease; however, it is not known whether these metabolic disruptions are linked to cognitive decline. Here, using unbiased lipidomic approaches and direct biochemical assessments, we profiled Land's cycle lipid remodeling in the hippocampus, frontal cortex, and temporal-parietal-entorhinal cortices of human amyloid beta precursor protein (ΑβPP) over-expressing mice. We identified a cortex-specific hypo-metabolic signature at symptomatic onset and a cortex-specific hyper-metabolic signature of Land's cycle glycerophosphocholine remodeling over the course of progressive behavioral decline. When N5 TgCRND8 and ΑβPP

Identifiants

DOI: 10.1111/jnc.14560 PMID: 30040874
pubmed: 30040874
doi: 10.1111/jnc.14560
doi:

Substances chimiques

Amyloid beta-Protein Precursor 0
Phosphatidylcholines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

499-517

Subventions

Organisme : CIHR
ID : MOP#311838
Pays : Canada

Informations de copyright

© 2018 International Society for Neurochemistry.

Auteurs

Matthew W Granger (MW)

Neural Regeneration Laboratory, Ottawa Institute of Systems Biology, Centre for Catalysis Research and Innovation, University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.

Hui Liu (H)

Department of Neurology, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai, China.

Caitlin F Fowler (CF)

Neural Regeneration Laboratory, Ottawa Institute of Systems Biology, Centre for Catalysis Research and Innovation, University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.

Alexandre P Blanchard (AP)

Neural Regeneration Laboratory, Ottawa Institute of Systems Biology, Centre for Catalysis Research and Innovation, University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.

Matthew W Taylor (MW)

Neural Regeneration Laboratory, Ottawa Institute of Systems Biology, Centre for Catalysis Research and Innovation, University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.

Samantha P M Sherman (SPM)

Neural Regeneration Laboratory, Ottawa Institute of Systems Biology, Centre for Catalysis Research and Innovation, University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.

Hongbin Xu (H)

Neural Regeneration Laboratory, Ottawa Institute of Systems Biology, Centre for Catalysis Research and Innovation, University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.

Weidong Le (W)

Department of Neurology, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai, China.
Center for Clinical Research on Neurological Diseases, the 1st Affiliated Hospital, Dailan Medical University, Dailan, China.

Steffany A L Bennett (SAL)

Neural Regeneration Laboratory, Ottawa Institute of Systems Biology, Centre for Catalysis Research and Innovation, University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0001-7944-5800

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Distinct disruptions in Land's cycle...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines sécrétoires inhibitrices de protéinases › Protéase nexines › Précurseur de la protéine bêta-amyloïde › Distinct disruptions in Land's cycle...
questionsmedicales.fr › Eucaryotes › Animaux › Distinct disruptions in Land's cycle...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Distinct disruptions in Land's cycle...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Distinct disruptions in Land's cycle...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Distinct disruptions in Land's cycle...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Distinct disruptions in Land's cycle...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Distinct disruptions in Land's cycle...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidylcholines › Distinct disruptions in Land's cycle...