Molecular imaging mass spectrometry for probing protein dynamics in neurodegenerative disease pathology.
Alzheimer's disease
beta-amyloid
imaging mass spectrometry
matrix-assisted laser desorption/ionization
molecular imaging
neurodegeneration
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
15
04
2018
revised:
03
07
2018
revised:
10
07
2018
accepted:
12
07
2018
pubmed:
25
7
2018
medline:
6
5
2020
entrez:
25
7
2018
Statut:
ppublish
Résumé
Recent advances in the understanding of basic pathological mechanisms in various neurological diseases depend directly on the development of novel bioanalytical technologies that allow sensitive and specific chemical imaging at high resolution in cells and tissues. Mass spectrometry-based molecular imaging (IMS) has gained increasing popularity in biomedical research for mapping the spatial distribution of molecular species in situ. The technology allows for comprehensive, untargeted delineation of in situ distribution profiles of metabolites, lipids, peptides and proteins. A major advantage of IMS over conventional histochemical techniques is its superior molecular specificity. Imaging mass spectrometry has therefore great potential for probing molecular regulations in CNS-derived tissues and cells for understanding neurodegenerative disease mechanism. The goal of this review is to familiarize the reader with the experimental workflow, instrumental developments and methodological challenges as well as to give a concise overview of the major advances and recent developments and applications of IMS-based protein and peptide profiling with particular focus on neurodegenerative diseases. This article is part of the Special Issue "Proteomics".
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
488-506Subventions
Organisme : Medical Research Council
ID : MR/S005145/1
Pays : United Kingdom
Informations de copyright
© 2018 International Society for Neurochemistry.
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