Dysregulation of iron metabolism in cancer stem cells.
Cancer stem cells
Ferritin
Ferroptosis
Iron
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
14
06
2018
revised:
18
07
2018
accepted:
20
07
2018
pubmed:
25
7
2018
medline:
15
2
2020
entrez:
25
7
2018
Statut:
ppublish
Résumé
Cancer stem cells (CSCs) are a distinct subpopulation of tumor cells endowed with stem-like properties. Importantly, CSCs can survive current standard therapies, resulting in metastatic disease and tumor recurrence. Here we describe the alterations of iron homeostasis occurring in CSCs, which in general are characterized by high intracellular iron content. Importantly, abnormalities of iron metabolism correlate with faster tumor growth and adverse prognosis in cancer patients. In line with the dependence of cancer on iron, we also discuss iron-dependent mechanisms as druggable pathways, as iron chelators have been considered for tumor therapy and new molecules currently proposed and studied as antineoplastic drugs may impinge on iron and its capacity to promote oxidative stress to have therapeutic value in cancer.
Identifiants
pubmed: 30040994
pii: S0891-5849(18)31259-0
doi: 10.1016/j.freeradbiomed.2018.07.015
pii:
doi:
Substances chimiques
Iron Chelating Agents
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
216-220Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.