Prediction of lumbar vertebral body compressive strength of overweight and obese older adults using morphed subject-specific finite-element models to evaluate the effects of weight loss.
Finite-element analysis
Lumbar spine strength
Obesity
Quantitative computed tomography
Weight loss
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
09
06
2018
accepted:
13
07
2018
pubmed:
26
7
2018
medline:
9
5
2019
entrez:
26
7
2018
Statut:
ppublish
Résumé
Diet and exercise can promote weight loss in older adults; however, there is potential to increase fracture risk due to loss of bone mineral density (BMD) known to accompany weight loss. Weight loss effects on measures of bone quality and strength are currently unknown. The purpose of this study is to develop subject-specific finite-element (FE) models of the lumbar spine and study the effect of intentional weight loss on bone strength in a pilot data set. Computed tomography (CT) scans of the lumbar spine of 30 overweight and obese (mean BMI = 29.7 ± 3.9 kg/m From baseline to 18-month post-weight loss intervention, there were statistically significant decreases in estimated bone strength (6.5% decrease; p < 0.05). Adjusting for baseline bone measures and gender revealed no statistically significant correlations between weight change and change in vBMD, cortical thickness, or bone strength. Integration of CT-based measures and FE models with conventional areal BMD can improve the understanding of the effects of intentional weight loss on bone health.
Sections du résumé
BACKGROUND
BACKGROUND
Diet and exercise can promote weight loss in older adults; however, there is potential to increase fracture risk due to loss of bone mineral density (BMD) known to accompany weight loss. Weight loss effects on measures of bone quality and strength are currently unknown.
AIMS
OBJECTIVE
The purpose of this study is to develop subject-specific finite-element (FE) models of the lumbar spine and study the effect of intentional weight loss on bone strength in a pilot data set.
METHODS
METHODS
Computed tomography (CT) scans of the lumbar spine of 30 overweight and obese (mean BMI = 29.7 ± 3.9 kg/m
RESULTS
RESULTS
From baseline to 18-month post-weight loss intervention, there were statistically significant decreases in estimated bone strength (6.5% decrease; p < 0.05). Adjusting for baseline bone measures and gender revealed no statistically significant correlations between weight change and change in vBMD, cortical thickness, or bone strength.
CONCLUSION
CONCLUSIONS
Integration of CT-based measures and FE models with conventional areal BMD can improve the understanding of the effects of intentional weight loss on bone health.
Identifiants
pubmed: 30043314
doi: 10.1007/s40520-018-1010-1
pii: 10.1007/s40520-018-1010-1
pmc: PMC6345622
mid: NIHMS1500898
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
491-501Subventions
Organisme : National Heart, Lung, and Blood Institute
ID : R18 HL076441
Organisme : National Institute on Aging
ID : P30 AG21332
Organisme : NIA NIH HHS
ID : K01 AG047921
Pays : United States
Organisme : National Institute on Aging
ID : K01 AG047921
Organisme : Directorate for Engineering
ID : 1559700
Organisme : NIA NIH HHS
ID : P30 AG021332
Pays : United States
Organisme : NHLBI NIH HHS
ID : R18 HL076441
Pays : United States
Références
Spine (Phila Pa 1976). 2001 Jul 15;26(14):1555-61
pubmed: 11462085
J Orthop Res. 2002 Jul;20(4):801-5
pubmed: 12168670
Spine (Phila Pa 1976). 2003 Mar 15;28(6):559-65
pubmed: 12642762
J Biomech. 2003 Jul;36(7):897-904
pubmed: 12757797
J Biomech Eng. 2003 Aug;125(4):434-8
pubmed: 12968567
Bone. 2003 Oct;33(4):744-50
pubmed: 14555280
Arch Intern Med. 2004 May 24;164(10):1108-12
pubmed: 15159268
Med Sci Sports Exerc. 2004 Nov;36(11):1985-96
pubmed: 15514517
J Bone Miner Res. 2005 Jan;20(1):131-40
pubmed: 15619679
Spine (Phila Pa 1976). 2006 Jul 15;31(16):1789-94
pubmed: 16845352
J Biomech Eng. 2006 Oct;128(5):641-6
pubmed: 16995749
Arch Intern Med. 2006 Dec 11-25;166(22):2502-10
pubmed: 17159017
Bone. 2007 Mar;40(3):767-74
pubmed: 17174619
Spine (Phila Pa 1976). 2007 Apr 20;32(9):1019-27
pubmed: 17450078
J Biomech. 2008;41(2):356-67
pubmed: 18022179
Spine (Phila Pa 1976). 2008 Jan 1;33(1):27-32
pubmed: 18165745
Comput Methods Biomech Biomed Engin. 2008 Oct;11(5):477-87
pubmed: 18608338
Med Eng Phys. 2008 Dec;30(10):1287-304
pubmed: 18986824
Osteoporos Int. 2009 Aug;20(8):1347-52
pubmed: 19039511
Spine (Phila Pa 1976). 2009 Jun 15;34(14):1464-9
pubmed: 19525837
Best Pract Res Clin Rheumatol. 2009 Dec;23(6):741-53
pubmed: 19945686
Med Image Anal. 2010 Jun;14(3):276-90
pubmed: 20163980
Osteoporos Int. 2012 Feb;23(2):563-72
pubmed: 21344244
J Bone Miner Res. 2011 Dec;26(12):2851-9
pubmed: 21786319
J Bone Miner Res. 2012 Apr;27(4):808-16
pubmed: 22190331
Clin Cases Miner Bone Metab. 2009 Sep;6(3):234-46
pubmed: 22461252
Med Image Anal. 2012 Jul;16(5):952-65
pubmed: 22465079
Annu Rev Nutr. 2012 Aug 21;32:287-309
pubmed: 22809104
J Clin Endocrinol Metab. 1990 Apr;70(4):1202-7
pubmed: 2318940
Bone Miner. 1990 Apr;9(1):71-81
pubmed: 2337690
J Gerontol A Biol Sci Med Sci. 2013 Oct;68(10):1236-42
pubmed: 23833201
Clin Biomech (Bristol, Avon). 1989;4 Suppl 2:iii-27
pubmed: 23906213
Clin Biomech (Bristol, Avon). 1994 May;9(3):180-6
pubmed: 23916179
J Bone Miner Res. 2014 Mar;29(3):570-80
pubmed: 23956027
Contemp Clin Trials. 2013 Nov;36(2):382-93
pubmed: 23974035
J Anat. 2014 Aug;225(2):246-61
pubmed: 24917069
BMJ. 2015 Jan 27;350:h25
pubmed: 25627698
J Bone Miner Res. 2015 Sep;30(9):1709-16
pubmed: 25753495
J Bone Miner Res. 2015 Dec;30(12):2168-78
pubmed: 26012544
Traffic Inj Prev. 2015;16 Suppl 1:S36-48
pubmed: 26027974
Traffic Inj Prev. 2015;16 Suppl 1:S57-65
pubmed: 26027976
Stapp Car Crash J. 2014 Nov;58:361-84
pubmed: 26192960
Bone. 1989;10(6):465-70
pubmed: 2624829
J Bone Miner Res. 2016 Jan;31(1):40-51
pubmed: 26332798
Comput Biol Med. 2015 Dec 1;67:41-8
pubmed: 26496701
Stapp Car Crash J. 2015 Nov;59:359-83
pubmed: 26660751
Osteoporos Int. 2016 Oct;27(10):2891-900
pubmed: 27262840
J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1547-1553
pubmed: 28064148
J Osteoporos Phys Act. 2018;6(1):null
pubmed: 29683141
J Bone Joint Surg Am. 1985 Oct;67(8):1206-14
pubmed: 4055845
J Bone Miner Res. 1994 May;9(5):687-93
pubmed: 8053398
BMJ. 1993 Jul 17;307(6897):172-3
pubmed: 8343746
J Spinal Disord. 1993 Apr;6(2):106-13
pubmed: 8504221
Osteoporos Int. 1996;6(2):160-5
pubmed: 8704356
Osteoporos Int. 1996;6(1):37-42
pubmed: 8845598
Bone. 1997 Aug;21(2):191-9
pubmed: 9267695
J Bone Miner Res. 1997 Oct;12(10):1721-8
pubmed: 9333134
Ann Intern Med. 1998 May 15;128(10):793-800
pubmed: 9599190
Med Eng Phys. 1998 Jan;20(1):1-10
pubmed: 9664280
J Biomech. 1998 Jul;31(7):601-8
pubmed: 9796682