Infant and childhood growth and frailty in old age: the Helsinki Birth Cohort Study.
Frailty
Growth
Life course
Risk factor
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
17
03
2018
accepted:
14
07
2018
pubmed:
26
7
2018
medline:
8
6
2019
entrez:
26
7
2018
Statut:
ppublish
Résumé
Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases. In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years. Greater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls. Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
Sections du résumé
BACKGROUND
BACKGROUND
Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases.
METHODS
METHODS
In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years.
RESULTS
RESULTS
Greater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls.
CONCLUSIONS
CONCLUSIONS
Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
Identifiants
pubmed: 30043315
doi: 10.1007/s40520-018-1011-0
pii: 10.1007/s40520-018-1011-0
pmc: PMC6240457
mid: EMS78933
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
717-721Subventions
Organisme : Medical Research Council
ID : MC_U147574242
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12011/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_A620_1017
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12011/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_A620_1016
Pays : United Kingdom
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