VASCULARIZED SARCOID GRANULOMA COMPLICATED BY PLACOID DISEASE IN A PEDIATRIC PATIENT.


Journal

Retinal cases & brief reports
ISSN: 1937-1578
Titre abrégé: Retin Cases Brief Rep
Pays: United States
ID NLM: 101298744

Informations de publication

Date de publication:
01 Jul 2021
Historique:
pubmed: 26 7 2018
medline: 1 12 2021
entrez: 26 7 2018
Statut: ppublish

Résumé

To report a case of pediatric vascularized sarcoid choroidal granuloma complicated by placoid-like inflammation. Case report. A 10-year-old girl presented with blurry vision in her right eye and a yellowish macular lesion that had been diagnosed as fibrotic choroidal neovascular membrane and observed for several months. On referral to our clinic, optical coherence tomography revealed a homogeneous hyperreflective lesion obliterating the choroidal vasculature and protruding under the retina with associated subretinal and intraretinal fluid. Optical coherence tomography angiography revealed vascularization of this granulomatous lesion, and the girl underwent six intravitreal injections of anti-vascular endothelial growth factor, with reabsorption of the fluid and consolidation of the lesion. A sudden, abrupt decrease in the visual acuity of the right eye 3 months after the last injection was accompanied on optical coherence tomography by hyperreflective inflammatory lesions breaking from the retinal pigment epithelium and involving the outer nuclear layer, all around the fibrotic granulomatous lesion. The girl was treated with oral steroids, and an extensive systemic evaluation revealed hilar adenopathy, thus posing the diagnosis of pediatric sarcoidosis complicated by placoid chorioretinopathy. Atypical presentations of typical uveitic diseases are quite common in children. The presence of a foveal vascularized granuloma complicated by a placoid disorder should prompt the exclusion of infectious etiologies such as tuberculosis, to establish a therapy to preserve the child's vision.

Identifiants

pubmed: 30045154
pii: 01271216-202107000-00019
doi: 10.1097/ICB.0000000000000806
doi:

Types de publication

Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

426-430

Références

Gupta A, Ramanan AV. Uveitis in children: diagnosis and management. Indian J Pediatr 2016;83:71–77.
Pichi F, Srivastava SK, Nucci P, et al. Peripheral retinoschisis in intermediate uveitis. Retina 2017;37:2167–2174.
Choi DE, Birnbaum AD, Oh F, et al. Pediatric uveitis secondary to probable, presumed, and biopsy-proven sarcoidosis. J Pediatr Ophthalmol Strabismus 2011;48:157–162.
Fauroux B, Clément A. Paediatric sarcoidosis. Paediatr Respir Rev 2005;6:128–133.
Holland GN, Rosenbaum JT. The challenge of Blau syndrome. Am J Ophthalmol 2018;187:xviii–xix.
Invernizzi A, Agarwal A, Di Nicola M, et al. Choroidal neovascular membranes secondary to intraocular tuberculosis misdiagnosed as neovascular age-related macular degeneration. Eur J Ophthalmol 2017;28:216–224.
Pichi F, Srivastava SK, Levinson A, et al. A focal chorioretinal bartonella lesion analyzed by optical coherence tomography angiography. Ophthalmic Surg Lasers Imaging Retina 2016;47:585–588.
Pichi F, Sarraf D, Arepalli S, et al. The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases. Prog Retin Eye Res 2017;59:178–201.
Klufas M, Phasukkijwatana N, Iafe NA, et al. Optical coherence tomography angiography reveals choriocapillaris flow reduction in placoid chorioretinitis. Ophthalmol Retina 2016;1:77–91.
Gupta V, Shoughy SS, Mahajan S, et al. Clinics of ocular tuberculosis. Ocul Immunol Inflamm 2015;23:14–24.

Auteurs

Francesco Pichi (F)

Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.

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Classifications MeSH