Hepatoprotective Effects of Algerian
Crataegus oxyacantha
antioxidant
doxorubicin
hepatoprotective
hepatotoxicity
oxidative stress.
Journal
Recent patents on food, nutrition & agriculture
ISSN: 1876-1429
Titre abrégé: Recent Pat Food Nutr Agric
Pays: United Arab Emirates
ID NLM: 101526178
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
03
2018
revised:
18
07
2018
accepted:
19
07
2018
pubmed:
31
7
2018
medline:
15
3
2019
entrez:
31
7
2018
Statut:
ppublish
Résumé
Hawthorn (C. oxyacantha), a common edible plant, is widely used for the preparation of a different foodstuff and is also used in traditional medicine to treat heart problems and gastrointestinal ailments. Recently, a few patents of Crataegus preparation for protective effects (prevention of cardiovascular and hepatic diseases) have been developed. The current study aimed to explore the antioxidant and hepatoprotective effects of nbutanol extract of Crataegus oxyacantha leaves in acute liver damage induced by Doxorubicin (DOX). Crataegus oxyacantha (100 mg/kg body weight) or vitamin E as a standard antioxidant (100 mg/kg body weight) were administered orally to female rats for 10 days, in the presence or absence of hepatotoxicity induced by a single intraperitoneal (i.p.) injection of DOX (15 mg/kg on the 8th day). On day 11, blood and liver samples were analyzed for biomarker levels and histopathological changes. Liver homogenates were used for determination of oxidative stress parameters that include Malondialdehyde (MDA), Glutathione (GSH) level and Glutathione Peroxidase (GPx) activity. Treatment with n-butanol extract of C. oxyacantha leaves significantly improved the altered liver enzyme activities and oxidative stress markers. The histopathological observations confirm the results of biochemical parameters. The obtained results support the traditional use of C. oxyacantha to cure gastrointestinal ailments and highlighted its possible use in the food and pharmaceutical industries as a source of natural antioxidant.
Sections du résumé
BACKGROUND
BACKGROUND
Hawthorn (C. oxyacantha), a common edible plant, is widely used for the preparation of a different foodstuff and is also used in traditional medicine to treat heart problems and gastrointestinal ailments. Recently, a few patents of Crataegus preparation for protective effects (prevention of cardiovascular and hepatic diseases) have been developed.
OBJECTIVE
OBJECTIVE
The current study aimed to explore the antioxidant and hepatoprotective effects of nbutanol extract of Crataegus oxyacantha leaves in acute liver damage induced by Doxorubicin (DOX).
METHODS
METHODS
Crataegus oxyacantha (100 mg/kg body weight) or vitamin E as a standard antioxidant (100 mg/kg body weight) were administered orally to female rats for 10 days, in the presence or absence of hepatotoxicity induced by a single intraperitoneal (i.p.) injection of DOX (15 mg/kg on the 8th day). On day 11, blood and liver samples were analyzed for biomarker levels and histopathological changes. Liver homogenates were used for determination of oxidative stress parameters that include Malondialdehyde (MDA), Glutathione (GSH) level and Glutathione Peroxidase (GPx) activity.
RESULTS
RESULTS
Treatment with n-butanol extract of C. oxyacantha leaves significantly improved the altered liver enzyme activities and oxidative stress markers. The histopathological observations confirm the results of biochemical parameters.
CONCLUSION
CONCLUSIONS
The obtained results support the traditional use of C. oxyacantha to cure gastrointestinal ailments and highlighted its possible use in the food and pharmaceutical industries as a source of natural antioxidant.
Identifiants
pubmed: 30058501
pii: FNA-EPUB-92008
doi: 10.2174/2212798410666180730095456
doi:
Substances chimiques
Plant Extracts
0
Malondialdehyde
4Y8F71G49Q
Doxorubicin
80168379AG
Glutathione Peroxidase
EC 1.11.1.9
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
70-75Informations de copyright
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