Daylight photodynamic therapy for the treatment of actinic cheilitis.
actinic cheilitis
daylight
photodynamic therapy
Journal
Photodermatology, photoimmunology & photomedicine
ISSN: 1600-0781
Titre abrégé: Photodermatol Photoimmunol Photomed
Pays: England
ID NLM: 9013641
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
07
05
2018
revised:
07
07
2018
accepted:
16
07
2018
pubmed:
2
8
2018
medline:
8
2
2019
entrez:
2
8
2018
Statut:
ppublish
Résumé
Actinic cheilitis (AC) is a common, chronic premalignant condition resulting from protracted sun exposure affecting the vermilion border of the lower lip. Treatment of AC aims at terminating the progression to squamous cell carcinoma by obliterating the primary lesion, and includes ablative methods; nonablative modalities such as cryotherapy, electrodessication, chemical peeling, topical imiquimod and 5-fluorouracil; and photodynamic therapy (PDT). Daylight-activated PDT, in which natural daylight serves as the light source, showed promising results in the treatment of actinic keratoses with substantially less pain than conventional PDT. To determine the safety and efficacy of daylight PDT in a series of patients with AC. Eleven patients with AC were treated with daylight PDT. All patients underwent repeated treatment sessions until clinical and histological remission were achieved. Cure rate was 91% (10 of 11 patients, three females/eight males; mean age 59.2 ± 14.4 years). Mean number of treatments to attain cure was 2.7. Patients experienced mild erythema and minimal to no pain during treatment. Daylight PDT is a promising modality for the treatment of AC, with impressive cosmetic results and few side effects.
Sections du résumé
BACKGROUND
BACKGROUND
Actinic cheilitis (AC) is a common, chronic premalignant condition resulting from protracted sun exposure affecting the vermilion border of the lower lip. Treatment of AC aims at terminating the progression to squamous cell carcinoma by obliterating the primary lesion, and includes ablative methods; nonablative modalities such as cryotherapy, electrodessication, chemical peeling, topical imiquimod and 5-fluorouracil; and photodynamic therapy (PDT). Daylight-activated PDT, in which natural daylight serves as the light source, showed promising results in the treatment of actinic keratoses with substantially less pain than conventional PDT.
PURPOSE
OBJECTIVE
To determine the safety and efficacy of daylight PDT in a series of patients with AC.
METHODS
METHODS
Eleven patients with AC were treated with daylight PDT. All patients underwent repeated treatment sessions until clinical and histological remission were achieved.
RESULTS
RESULTS
Cure rate was 91% (10 of 11 patients, three females/eight males; mean age 59.2 ± 14.4 years). Mean number of treatments to attain cure was 2.7. Patients experienced mild erythema and minimal to no pain during treatment.
CONCLUSIONS
CONCLUSIONS
Daylight PDT is a promising modality for the treatment of AC, with impressive cosmetic results and few side effects.
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11-16Informations de copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.