Laminins and their receptors in the CNS.
blood-brain barrier
integrin
laminin
neurodegeneration
stroke
Journal
Biological reviews of the Cambridge Philosophical Society
ISSN: 1469-185X
Titre abrégé: Biol Rev Camb Philos Soc
Pays: England
ID NLM: 0414576
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
revised:
05
07
2018
received:
20
04
2018
accepted:
09
07
2018
pubmed:
4
8
2018
medline:
4
8
2018
entrez:
4
8
2018
Statut:
ppublish
Résumé
Laminin, an extracellular matrix protein, is widely expressed in the central nervous system (CNS). By interacting with integrin and non-integrin receptors, laminin exerts a large variety of important functions in the CNS in both physiological and pathological conditions. Due to the existence of many laminin isoforms and their differential expression in various cell types in the CNS, the exact functions of each individual laminin molecule in CNS development and homeostasis remain largely unclear. In this review, we first briefly introduce the structure and biochemistry of laminins and their receptors. Next, the dynamic expression of laminins and their receptors in the CNS during both development and in adulthood is summarized in a cell-type-specific manner, which allows appreciation of their functional redundancy/compensation. Furthermore, we discuss the biological functions of laminins and their receptors in CNS development, blood-brain barrier (BBB) maintenance, neurodegeneration, stroke, and neuroinflammation. Last, key challenges and potential future research directions are summarized and discussed. Our goals are to provide a synthetic review to stimulate future studies and promote the formation of new ideas/hypotheses and new lines of research in this field.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
283-306Subventions
Organisme : American Heart Association Scientist Development
ID : 16SDG29320001
Informations de copyright
© 2018 Cambridge Philosophical Society.
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