Genetic access to neurons in the accessory optic system reveals a role for Sema6A in midbrain circuitry mediating motion perception.
Accessory optic system
Medial terminal nucleus
RRID: AB_2079751
RRID: IMSR_JAX:007914
RRID:AB_10000240
RRID:AB_2209751
RRID:AB_2492226
RRID:IMSR_JAX:005029
RRID:MGI:3037891
Retinal ganglion cells
Sema6A.
Journal
The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
received:
29
05
2018
revised:
18
07
2018
accepted:
19
07
2018
pubmed:
5
8
2018
medline:
17
4
2020
entrez:
5
8
2018
Statut:
ppublish
Résumé
The accessory optic system (AOS) detects retinal image slip and reports it to the oculomotor system for reflexive image stabilization. Here, we characterize two Cre lines that permit genetic access to AOS circuits responding to vertical motion. The first (Pcdh9-Cre) labels only one of the four subtypes of ON direction-selective retinal ganglion cells (ON-DS RGCs), those preferring ventral retinal motion. Their axons diverge from the optic tract just behind the chiasm and selectively innervate the medial terminal nucleus (MTN) of the AOS. Unlike most RGC subtypes examined, they survive after optic nerve crush. The second Cre-driver line (Pdzk1ip1-Cre) labels postsynaptic neurons in the MTN. These project predominantly to the other major terminal nucleus of the AOS, the nucleus of the optic tract (NOT). We find that the transmembrane protein semaphorin 6A (Sema6A) is required for the formation of axonal projections from the MTN to the NOT, just as it is for the retinal innervation of the MTN. These new tools permit manipulation of specific circuits in the AOS and show that Sema6A is required for establishing AOS connections in multiple locations.
Identifiants
pubmed: 30076594
doi: 10.1002/cne.24507
pmc: PMC6312510
mid: NIHMS1502579
doi:
Substances chimiques
Sema6a protein, mouse
0
Semaphorins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
282-296Subventions
Organisme : NINDS NIH HHS
ID : P30 NS050274
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY012793
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY027713
Pays : United States
Informations de copyright
© 2018 Wiley Periodicals, Inc.
Références
Nature. 2016 Apr 14;532(7598):236-9
pubmed: 27049951
Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):E2391-8
pubmed: 22891316
PLoS One. 2008 Feb 06;3(2):e1533
pubmed: 18253481
Cell Rep. 2018 Feb 6;22(6):1462-1472
pubmed: 29425502
Science. 2008 Nov 7;322(5903):963-6
pubmed: 18988856
Neuron. 2015 Mar 18;85(6):1244-56
pubmed: 25754821
J Neurophysiol. 1988 Dec;60(6):2055-72
pubmed: 3236061
Nature. 2015 Aug 27;524(7566):466-470
pubmed: 26287463
Cell Rep. 2017 Feb 21;18(8):2058-2072
pubmed: 28228269
Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2303-7
pubmed: 10688875
Cell. 2002 Aug 9;110(3):385-97
pubmed: 12176325
J Comp Neurol. 2014 Apr 15;522(6):1411-43
pubmed: 24318667
Cell Metab. 2018 Jan 9;27(1):226-236.e3
pubmed: 29320703
Nat Neurosci. 2010 Jan;13(1):133-40
pubmed: 20023653
Nature. 2008 Mar 27;452(7186):478-82
pubmed: 18368118
Bioinformatics. 2009 Jun 1;25(11):1463-5
pubmed: 19346324
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4045-50
pubmed: 23431148
Neuron. 2010 Jul 15;67(1):49-60
pubmed: 20624591
Cerebellum. 2015 Oct;14(5):528-33
pubmed: 26129714
Vision Res. 2004 Dec;44(28):3419-27
pubmed: 15536010
J Neurosci. 2010 Sep 15;30(37):12495-507
pubmed: 20844144
eNeuro. 2017 May 1;4(2):
pubmed: 28466070
J Neurosci. 2013 Jul 3;33(27):10972-85
pubmed: 23825403
J Comp Neurol. 1987 Aug 1;262(1):141-58
pubmed: 3624547
Neuron. 2016 Oct 19;92(2):372-382
pubmed: 27720486
Vis Neurosci. 1991 Feb;6(2):95-111
pubmed: 2049333
Neuron. 2015 May 20;86(4):971-984
pubmed: 25959730
Cell. 2014 Aug 14;158(4):793-807
pubmed: 25126785
Annu Rev Neurosci. 1984;7:13-41
pubmed: 6370078
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1937-42
pubmed: 26831088
PLoS One. 2015 Feb 23;10(2):e0117570
pubmed: 25706871
Prog Brain Res. 2006;151:407-40
pubmed: 16221596
J Neurosci. 2013 Nov 6;33(45):17797-813
pubmed: 24198370
Ophthalmology. 2012 May;119(5):979-86
pubmed: 22349567
J Physiol. 1965 Jun;178(3):477-504
pubmed: 5827909
J Neurosci. 2000 Jun 15;20(12):4615-26
pubmed: 10844031
Science. 2013 Nov 1;342(6158):1241974
pubmed: 24179230
Neuron. 2011 Aug 25;71(4):683-94
pubmed: 21867884
Annu Rev Neurosci. 2017 Jul 25;40:211-230
pubmed: 28418757
J Comp Neurol. 1992 Nov 15;325(3):327-42
pubmed: 1447405
Vision Res. 1972 Feb;12(2):183-93
pubmed: 5033683
J Physiol. 2006 Oct 1;576(Pt 1):197-202
pubmed: 16901944
Nat Neurosci. 2005 Nov;8(11):1516-24
pubmed: 16205717
Annu Rev Neurosci. 2015 Jul 8;38:221-46
pubmed: 25897874
Nature. 2017 Jun 22;546(7659):492-497
pubmed: 28607486
J Comp Neurol. 1985 Feb 1;232(1):99-116
pubmed: 3973086
J Neurosci. 2011 May 25;31(21):7753-62
pubmed: 21613488
Annu Rev Neurosci. 2017 Jul 25;40:395-424
pubmed: 28460185
Invest Ophthalmol Vis Sci. 2015 Sep;56(10):6095-112
pubmed: 26393669
PLoS One. 2009;4(1):e4320
pubmed: 19177171
J Comp Neurol. 1984 Aug 1;227(2):228-51
pubmed: 6470215
Nature. 2011 Jan 20;469(7330):407-10
pubmed: 21170022
Neuron. 2015 May 20;86(4):985-999
pubmed: 25959733
Neuron. 2009 May 14;62(3):327-34
pubmed: 19447089
J Gen Physiol. 2000 Dec;116(6):791-4
pubmed: 11099348