Lysosomal phospholipase A2.
Antigen presentation
Ceramide
Lysosome
Phospholipase A2
Phospholipidosis
Tuberculosis
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
17
06
2018
revised:
23
07
2018
accepted:
24
07
2018
pubmed:
5
8
2018
medline:
15
1
2020
entrez:
5
8
2018
Statut:
ppublish
Résumé
Lysosomal phospholipase A2 (PLA2G15) is a ubiquitous enzyme uniquely characterized by a subcellular localization to the lysosome and late endosome. PLA2G15 has an acidic pH optimum, is calcium independent, and acts as a transacylase in the presence of N-acetyl-sphingosine as an acceptor. Recent studies aided by the delineation of the crystal structure of PLA2G15 have clarified further the catalytic mechanism, sn-1 versus sn-2 specificity, and the basis whereby cationic amphiphilic drugs inhibit its activity. PLA2G15 has recently been shown to hydrolyze short chain oxidized phospholipids which access the catalytic site directly based on their aqueous solubility. Studies on the PLA2G15 null mouse suggest a role for the enzyme in the catabolism of pulmonary surfactant. PLA2G15 may also have a role in host defense and in the processing of lipid antigens for presentation by CD1 proteins. This article is part of a Special Issue entitled Novel functions of phospholipase A2 Guest Editors: Makoto Murakami and Gerard Lambeau.
Identifiants
pubmed: 30077006
pii: S1388-1981(18)30182-3
doi: 10.1016/j.bbalip.2018.07.012
pmc: PMC6361722
mid: NIHMS1503190
pii:
doi:
Substances chimiques
Phospholipids
0
Phospholipases A2
EC 3.1.1.4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
932-940Subventions
Organisme : BLRD VA
ID : I01 BX002021
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR056991
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122416
Pays : United States
Organisme : NINDS NIH HHS
ID : UH3 NS092981
Pays : United States
Informations de copyright
Published by Elsevier B.V.
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