Toxic medications in Leber's hereditary optic neuropathy.

Drug-Related Side Effects and Adverse Reactions Humans Optic Atrophy, Hereditary, Leber / pathology Reactive Oxygen Species / metabolism
Antimicrobials Leber's hereditary optic neuropathy Medications Mitochondrial toxicity

Journal

Mitochondrion
ISSN: 1872-8278
Titre abrégé: Mitochondrion
Pays: Netherlands
ID NLM: 100968751

Informations de publication

Date de publication:
05 2019
Historique:
received: 14 03 2018
revised: 23 05 2018
accepted: 31 07 2018
pubmed: 7 8 2018
medline: 17 8 2019
entrez: 7 8 2018
Statut: ppublish

Résumé

Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder characterized by acute bilateral vision loss. The pathophysiology involves reactive oxygen species (ROS), which can be affected by medications. This article reviews the evidence for medications with demonstrated and theoretical effects on mitochondrial function, specifically in relation to increased ROS production. The data reviewed provides guidance when selecting medications for individuals with LHON mutations (carriers) and are susceptible to conversion to affected. However, as with all medications, the proven benefits of these therapies must be weighed against, in some cases, purely theoretical risks for this unique patient population.

Identifiants

DOI: 10.1016/j.mito.2018.07.007 PMID: 30081212
pubmed: 30081212
pii: S1567-7249(18)30036-9
doi: 10.1016/j.mito.2018.07.007
pii:
doi:

Substances chimiques

Reactive Oxygen Species 0

Types de publication

Journal Article Review

Langues

eng

Pagination

270-277

Informations de copyright

Copyright © 2018 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

Auteurs

Kaitlin Kogachi (K)

Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA. Electronic address: kaitlin9210@gmail.com.

Anna Ter-Zakarian (A)

Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA.

Samuel Asanad (S)

Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA; Doheny Eye Center, Department of Ophthalmology, David Geffen School of Medicine at UCLA, 800 South Fairmount Avenue, Suite 215, Pasadena, CA 91105, USA.

Alfredo Sadun (A)

Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA; Doheny Eye Center, Department of Ophthalmology, David Geffen School of Medicine at UCLA, 800 South Fairmount Avenue, Suite 215, Pasadena, CA 91105, USA.

Rustum Karanjia (R)

Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA; Doheny Eye Center, Department of Ophthalmology, David Geffen School of Medicine at UCLA, 800 South Fairmount Avenue, Suite 215, Pasadena, CA 91105, USA; The Ottawa Eye Institute, University of Ottawa, 501 Smyth Rd, Ottawa, ON K1H 8M2, Canada; Ottawa Hospital Research Institute, 1053 Carling Avenue, Ottawa, ON K1Y 4E9, Canada.

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Classifications MeSH

questionsmedicales.fr › Troubles dus à des produits chimiques › Effets secondaires indésirables des médicaments › Toxic medications in Leber's hereditary optic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Toxic medications in Leber's hereditary optic...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies mitochondriales › Atrophie optique héréditaire de Leber › Toxic medications in Leber's hereditary optic...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Toxic medications in Leber's hereditary optic...