Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.
Animals
Autophagy
/ genetics
Autophagy-Related Protein 7
/ genetics
Carrier Proteins
/ metabolism
Cell Differentiation
/ genetics
Cells, Cultured
Insulin-Like Growth Factor I
/ metabolism
Mice
Mice, Knockout
Muscle Development
/ genetics
Muscle, Skeletal
/ embryology
NF-E2-Related Factor 1
/ genetics
PAX7 Transcription Factor
/ genetics
Satellite Cells, Skeletal Muscle
/ cytology
Signal Transduction
/ genetics
Transcription Factor CHOP
/ genetics
DDIT3
GHR
NFE2L2
development
dwarf mice
muscle
satellite cells
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
pubmed:
8
8
2018
medline:
13
3
2020
entrez:
8
8
2018
Statut:
ppublish
Résumé
Macroautophagy/autophagy is emerging as an important process in adult muscle stem cells functions: it regulates metabolic reprogramming during activation from a quiescent state, maintains stemness and prevents senescence. We now show that autophagy is specifically required for neonatal myogenesis and muscle development. Specific deletion of Atg7 in PAX7
Identifiants
pubmed: 30081710
doi: 10.1080/15548627.2018.1507439
pmc: PMC6287695
doi:
Substances chimiques
Atg7 protein, mouse
0
Carrier Proteins
0
Ddit3 protein, mouse
0
NF-E2-Related Factor 1
0
Nfe2L1 protein, mouse
0
PAX7 Transcription Factor
0
Pax7 protein, mouse
0
insulin-like growth factor-1, mouse
0
Transcription Factor CHOP
147336-12-7
Insulin-Like Growth Factor I
67763-96-6
Autophagy-Related Protein 7
EC 6.2.1.45
somatotropin-binding protein
W06KFL3RDT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
58-77Références
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