Non-reproductive Functions of Aromatase in the Central Nervous System Under Physiological and Pathological Conditions.
Astrocytes
Neuroinflammation
Neuroprotection
Radial glia
Sex differences
Synapses
Journal
Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
03
07
2018
accepted:
25
07
2018
pubmed:
8
8
2018
medline:
18
5
2019
entrez:
8
8
2018
Statut:
ppublish
Résumé
The modulation of brain function and behavior by steroid hormones was classically associated with their secretion by peripheral endocrine glands. The discovery that the brain expresses the enzyme aromatase, which produces estradiol from testosterone, expanded this traditional concept. One of the best-studied roles of brain estradiol synthesis is the control of reproductive behavior. In addition, there is increasing evidence that estradiol from neural origin is also involved in a variety of non-reproductive functions. These include the regulation of neurogenesis, neuronal development, synaptic transmission, and plasticity in brain regions not directly related with the control of reproduction. Central aromatase is also involved in the modulation of cognition, mood, and non-reproductive behaviors. Furthermore, under pathological conditions aromatase is upregulated in the central nervous system. This upregulation represents a neuroprotective and likely also a reparative response by increasing local estradiol levels in order to maintain the homeostasis of the neural tissue. In this paper, we review the non-reproductive functions of neural aromatase and neural-derived estradiol under physiological and pathological conditions. We also consider the existence of sex differences in the role of the enzyme in both contexts.
Identifiants
pubmed: 30084008
doi: 10.1007/s10571-018-0607-4
pii: 10.1007/s10571-018-0607-4
doi:
Substances chimiques
Aromatase
EC 1.14.14.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
473-481Subventions
Organisme : Agencia Estatal de Investigación, Spain
ID : BFU2017-82754-R
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