Association of body mass index and diastolic function in metabolically healthy obese with preserved ejection fraction.
BMI
Diastolic dysfunction
HFpEF
Metabolically healthy
Obesity
Journal
International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291
Informations de publication
Date de publication:
15 Feb 2019
15 Feb 2019
Historique:
received:
03
06
2018
revised:
23
07
2018
accepted:
03
08
2018
pubmed:
12
8
2018
medline:
4
9
2019
entrez:
12
8
2018
Statut:
ppublish
Résumé
Small scale cohorts demonstrated an association between body mass index (BMI) and diastolic function in a metabolically healthy population. We aimed to characterize the relation between BMI and diastolic function in a relatively large cohort of metabolically healthy obese with preserved ejection fraction. Echocardiograms of metabolically healthy patients between 2011 and 2016, who had no significant valvulopathies or atrial fibrillation, and had preserved ejection fraction, were retrospectively identified and analyzed. Metabolically healthy was defined as lack of known diabetes mellitus, hypertension, and hyperlipidemia. Patients were categorized into 4 groups according to BMI - normal BMI 18.5-25, overweight 25.01-30, obese 30.01-35, morbidly obese >35 kg/m High BMI is associated with increased risk of diastolic dysfunction even in metabolically healthy patients. Additional trials are needed in order to evaluate whether these echocardiographic findings translate into clinical implications.
Sections du résumé
BACKGROUND
BACKGROUND
Small scale cohorts demonstrated an association between body mass index (BMI) and diastolic function in a metabolically healthy population. We aimed to characterize the relation between BMI and diastolic function in a relatively large cohort of metabolically healthy obese with preserved ejection fraction.
METHODS AND RESULTS
RESULTS
Echocardiograms of metabolically healthy patients between 2011 and 2016, who had no significant valvulopathies or atrial fibrillation, and had preserved ejection fraction, were retrospectively identified and analyzed. Metabolically healthy was defined as lack of known diabetes mellitus, hypertension, and hyperlipidemia. Patients were categorized into 4 groups according to BMI - normal BMI 18.5-25, overweight 25.01-30, obese 30.01-35, morbidly obese >35 kg/m
CONCLUSION
CONCLUSIONS
High BMI is associated with increased risk of diastolic dysfunction even in metabolically healthy patients. Additional trials are needed in order to evaluate whether these echocardiographic findings translate into clinical implications.
Identifiants
pubmed: 30097335
pii: S0167-5273(18)33591-5
doi: 10.1016/j.ijcard.2018.08.008
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
147-152Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.