Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications.
beta-sheet and helical peptides
biopolymers
collagen mimetic peptides
conjugation
hydrogels
peptide-polymer hybrids
self-assembly
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
11
06
2018
revised:
14
07
2018
pubmed:
14
8
2018
medline:
30
8
2019
entrez:
14
8
2018
Statut:
ppublish
Résumé
Peptides and polymers are the "elite" building blocks in hydrogel fabrication where the typical approach consists of coupling specific peptide sequences (cell adhesive and/or enzymatically cleavable) to polymer chains aiming to obtain controlled cell responses (adhesion, migration, differentiation). However, the use of polymers and peptides as structural components for fabricating supramolecular hydrogels is less well established. Here, the literature on the design of peptide/polymer systems for self-assembly into hybrid hydrogels, as either peptide-polymer conjugates or combining both components individually, is reviewed. The properties (stiffness, mesh structure, responsiveness, and biocompatibility) of the hydrogels are then discussed from the viewpoint of their potential biomedical applications.
Identifiants
pubmed: 30101512
doi: 10.1002/mabi.201800221
doi:
Substances chimiques
Hydrogels
0
Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1800221Informations de copyright
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.