The Osteoinductive Effect of Controlled Bone Morphogenic Protein 2 Release Is Location Dependent.
application sites
bone morphogenetic protein 2
bone tissue engineering
oligo[(polyethylene glycol) fumarate]
Journal
Tissue engineering. Part A
ISSN: 1937-335X
Titre abrégé: Tissue Eng Part A
Pays: United States
ID NLM: 101466659
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
pubmed:
14
8
2018
medline:
15
8
2019
entrez:
14
8
2018
Statut:
ppublish
Résumé
The main challenge in bone morphogenic protein 2 (BMP-2)-based application lies in finding strategies to prolong its biologic activity as it has a short biological half-life. The present study uses a phosphate-modified oligo[(polyethylene glycol) fumarate] hydrogel that can be tuned to achieve differential release profiles of biologically active BMP-2 release. We demonstrate that this platform outperforms Infuse
Identifiants
pubmed: 30101676
doi: 10.1089/ten.TEA.2017.0427
pmc: PMC6388716
doi:
Substances chimiques
BMP2 protein, human
0
Bone Morphogenetic Protein 2
0
Delayed-Action Preparations
0
Hydrogels
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
193-202Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR045871
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB003060
Pays : United States
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