Regulation of human brown adipose tissue by adenosine and A
Adenosine
/ pharmacology
Adipose Tissue, Brown
/ blood supply
Adolescent
Adult
Cold Temperature
Energy Metabolism
/ drug effects
Fatty Acids, Nonesterified
/ metabolism
Female
Humans
Male
Norepinephrine
/ metabolism
Oxygen Radioisotopes
Positron Emission Tomography Computed Tomography
Receptor, Adenosine A2A
/ metabolism
Regional Blood Flow
/ drug effects
Water
Xanthines
Young Adult
A2A receptor
Adenosine
Brown adipose tissue
Perfusion
Physiology
Positron emission tomography
[11C]TMSX
[15O]H2O
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
07
01
2018
accepted:
01
08
2018
pubmed:
15
8
2018
medline:
14
6
2019
entrez:
15
8
2018
Statut:
ppublish
Résumé
Brown adipose tissue (BAT) has emerged as a potential target to combat obesity and diabetes, but novel strategies to activate BAT are needed. Adenosine and A Healthy, lean men (n = 10) participated in PET/CT imaging with two radioligands. Perfusion of BAT, white adipose tissue (WAT) and muscle was quantified with [ Adenosine increased the perfusion of BAT even more than cold exposure (baseline 8.3 ± 4.5, cold 19.6 ± 9.3, adenosine 28.6 ± 7.9 ml/100 g/min, p < 0.01). Distribution volume of [ Adenosine administration caused a maximal perfusion effect in human supraclavicular BAT, indicating increased oxidative metabolism. Cold exposure increased noradrenaline concentrations and decreased the density of A2AR available for radioligand binding in BAT, suggesting augmented release of endogenous adenosine. Our results show that adenosine and A2AR are relevant for activation of human BAT, and A2AR provides a future target for enhancing BAT metabolism.
Identifiants
pubmed: 30105585
doi: 10.1007/s00259-018-4120-2
pii: 10.1007/s00259-018-4120-2
pmc: PMC6351510
doi:
Substances chimiques
Fatty Acids, Nonesterified
0
KF18446
0
Oxygen Radioisotopes
0
Oxygen-15
0
Receptor, Adenosine A2A
0
Xanthines
0
Water
059QF0KO0R
Adenosine
K72T3FS567
Norepinephrine
X4W3ENH1CV
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
743-750Commentaires et corrections
Type : ErratumIn
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