Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle.
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
08
05
2018
accepted:
30
07
2018
pubmed:
15
8
2018
medline:
31
3
2020
entrez:
15
8
2018
Statut:
ppublish
Résumé
Precision medicine aims to use patient genomic, epigenomic, specific drug dose, and other data to define disease patterns that may potentially lead to an improved treatment outcome. Personalized dosing regimens based on tumor drug penetration can play a critical role in this approach. State-of-the-art techniques to measure tumor drug penetration focus on systemic exposure, tissue penetration, cellular or molecular engagement, and expression of pharmacological activity. Using in silico methods, this information can be integrated to bridge the gap between the therapeutic regimen and the pharmacological link with clinical outcome. These methodologies are described, and challenges ahead are discussed. Supported by many examples, this review shows how the combination of these techniques provides enhanced patient-specific information on drug accessibility at the tumor tissue level, target binding, and downstream pharmacology. Our vision of how to apply tumor drug penetration measurements offers a roadmap for the clinical implementation of precision dosing.
Identifiants
pubmed: 30107040
doi: 10.1002/cpt.1211
pmc: PMC6617978
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
148-163Informations de copyright
© 2018 The Authors Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.
Références
Breast Cancer Res Treat. 2009 Feb;113(3):509-17
pubmed: 18327670
J Cell Biol. 2012 Feb 20;196(4):395-406
pubmed: 22351925
J Nucl Med. 2016 Jan;57(1):27-33
pubmed: 26449837
Anal Chem. 2011 Mar 15;83(6):2112-8
pubmed: 21332183
Breast Cancer Res. 2017 Sep 11;19(1):107
pubmed: 28893315
Oncotarget. 2016 May 31;7(22):32532-42
pubmed: 27081038
Eur J Nucl Med Mol Imaging. 2017 Mar;44(3):500-508
pubmed: 27872957
Cancer Res. 2018 Feb 1;78(3):758-768
pubmed: 29217763
Clin Cancer Res. 2018 Jul 15;24(14):3236-3238
pubmed: 29581133
Cancer Res. 2017 May 1;77(9):2318-2327
pubmed: 28461564
ACS Infect Dis. 2016 Aug 12;2(8):552-63
pubmed: 27626295
Nat Rev Cancer. 2016 May;16(5):275-87
pubmed: 27079802
AAPS J. 2005 Oct 24;7(3):E659-67
pubmed: 16353942
J Clin Oncol. 2013 Oct 1;31(28):3525-30
pubmed: 24002508
J Natl Cancer Inst. 2015 May 19;107(8):
pubmed: 25991002
Clin Chem. 2010 Jun;56(6):998-1006
pubmed: 20378769
Science. 1987 Jan 9;235(4785):177-82
pubmed: 3798106
Clin Pharmacol Ther. 2009 Jul;86(1):97-100
pubmed: 19440188
Eur J Radiol. 2014 Jan;83(1):103-10
pubmed: 24168926
Sci Rep. 2015 Aug 27;5:13545
pubmed: 26310312
Australas Phys Eng Sci Med. 2015 Mar;38(1):7-22
pubmed: 25427548
Lancet. 2010 Apr 24;375(9724):1437-46
pubmed: 20398925
Sci Transl Med. 2012 Mar 28;4(127):127ra37
pubmed: 22461641
J Control Release. 2015 Mar 10;201:78-89
pubmed: 25526702
Nat Methods. 2014 Apr;11(4):417-22
pubmed: 24584193
J Clin Oncol. 2017 Aug 1;35(22):2558-2567
pubmed: 28574779
Cancer Discov. 2015 Jan;5(1):72-81
pubmed: 25380844
IEEE J Biomed Health Inform. 2014 May;18(3):840-54
pubmed: 24108720
Ann Oncol. 2016 Apr;27(4):619-24
pubmed: 26598545
Anal Chem. 2013 Nov 5;85(21):10099-106
pubmed: 24024735
PLoS One. 2011;6(9):e24696
pubmed: 21935441
Nat Rev Clin Oncol. 2014 Feb;11(2):81-90
pubmed: 24281059
Nat Rev Clin Oncol. 2015 Dec;12(12):693-704
pubmed: 26196250
Drug Discov Today. 2012 May;17(9-10):419-24
pubmed: 22227532
J Control Release. 2016 Oct 28;240:202-211
pubmed: 26686082
Int J Appl Basic Med Res. 2012 Jan;2(1):3-6
pubmed: 23776799
Lancet Oncol. 2012 Aug;13(8):790-801
pubmed: 22658655
Drug Resist Updat. 2012 Feb-Apr;15(1-2):62-9
pubmed: 22409994
Br J Cancer. 2013 Sep 3;109(5):1223-9
pubmed: 23942068
J Clin Oncol. 2006 Sep 1;24(25):4054-5
pubmed: 16943522
Proteomics. 2014 Sep;14(17-18):1963-70
pubmed: 25044963
Curr Pharm Biotechnol. 2013;14(7):693-707
pubmed: 24372237
Clin Pharmacol Ther. 2017 May;101(5):646-656
pubmed: 28182269
Clin Transl Sci. 2017 May;10(3):133-142
pubmed: 28160433
Int J Cancer. 2002 Jun 20;99(6):783-91
pubmed: 12115478
Nat Med. 2014 Apr;20(4):436-42
pubmed: 24584119
Nature. 2014 Nov 27;515(7528):568-71
pubmed: 25428505
Clin Pharmacol Ther. 2010 May;87(5):586-92
pubmed: 20357763
Clin Pharmacol Ther. 2018 Apr;103(4):631-642
pubmed: 29243223
Clin Cancer Res. 2015 Aug 15;21(16):3658-66
pubmed: 25904751
Sci Rep. 2015 Jun 29;5:10169
pubmed: 26120042
N Engl J Med. 2017 Jun 22;376(25):2483-2485
pubmed: 28636845
J Nucl Med. 2008 Apr;49(4):517-23
pubmed: 18344436
JAMA Oncol. 2017 May 01;3(5):695-701
pubmed: 28033451
Expert Opin Drug Deliv. 2016 Jun;13(6):873-89
pubmed: 26981891
PET Clin. 2014 Jan;9(1):83-90
pubmed: 25029937
J Proteomics. 2011 Jun 10;74(7):982-92
pubmed: 21440690
J Nucl Med. 2017 Sep;58(Suppl 2):83S-90S
pubmed: 28864618
Front Oncol. 2017 Sep 19;7:219
pubmed: 28971064
Expert Opin Drug Deliv. 2015 May;12(5):793-812
pubmed: 25518870
Anal Bioanal Chem. 2008 May;391(2):577-85
pubmed: 18385987
Hematol Oncol Clin North Am. 2016 Feb;30(1):179-91
pubmed: 26614376
Ann Biomed Eng. 2016 Sep;44(9):2626-41
pubmed: 27384942
Clin Transl Imaging. 2014;2:55-66
pubmed: 24765618
Br J Cancer. 2018 Jan;118(1):9-16
pubmed: 29319049
J Nucl Med. 2015 Feb;56(2):177-82
pubmed: 25593115
Cancer. 2018 Apr 1;124(7):1449-1454
pubmed: 29315500
Cancer Res. 1992 Oct 1;52(19):5144-53
pubmed: 1327501
Mol Imaging Biol. 2014 Jun;16(3):431-40
pubmed: 24170452
N Engl J Med. 2017 Jan 12;376(2):125-135
pubmed: 28076709
Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10304-9
pubmed: 27551071
Cancer Res. 2017 Feb 1;77(3):623-631
pubmed: 27879266
Cancer Biol Med. 2014 Mar;11(1):20-33
pubmed: 24738036
Cancer Res. 2006 Jul 1;66(13):6732-40
pubmed: 16818648
Nat Commun. 2013;4:2718
pubmed: 24177351
Clin Cancer Res. 2018 Jul 15;24(14):3325-3333
pubmed: 29463551
J Neurooncol. 2009 Jan;91(1):51-8
pubmed: 18787762
Clin Cancer Res. 2017 Jun 15;23(12):3053-3060
pubmed: 28011460
Oncotarget. 2017 Oct 23;8(58):99161-99178
pubmed: 29228761
J Thorac Dis. 2010 Dec;2(4):245-52
pubmed: 22263053
J Mol Diagn. 2017 Mar;19(2):313-327
pubmed: 28188106
Clin Pharmacokinet. 2010 Aug;49(8):493-507
pubmed: 20608753
J Nucl Med. 2018 Mar;59(3):410-417
pubmed: 28818991
J Clin Oncol. 2012 Sep 20;30(27):3345-52
pubmed: 22891266
Clin Pharmacol Ther. 2017 May;101(5):657-666
pubmed: 28182273
Bioconjug Chem. 2017 Mar 15;28(3):846-856
pubmed: 28122451
Biochem Pharmacol. 2006 Jun 28;72(1):1-10
pubmed: 16469301
Clin Cancer Res. 1996 Nov;2(11):1829-35
pubmed: 9816137
Curr Opin Chem Eng. 2013 Nov;2(4):
pubmed: 24358455
Br J Clin Pharmacol. 2016 May;81(5):941-8
pubmed: 26714164
AAPS J. 2016 Sep;18(5):1117-1130
pubmed: 27287046
Sci Transl Med. 2017 May 10;9(389):
pubmed: 28490665
Eur J Nucl Med. 1993 Aug;20(8):716-31
pubmed: 8404961
Semin Oncol. 2011 Feb;38(1):55-69
pubmed: 21362516
Cancer Chemother Pharmacol. 2014 Apr;73(4):737-47
pubmed: 24519752
Oncotarget. 2017 Apr 10;8(34):56185-56198
pubmed: 28915583
J Biol Chem. 2010 Dec 17;285(51):39835-43
pubmed: 20940293
Sci Rep. 2016 May 05;6:25424
pubmed: 27147293
Clin Cancer Res. 2014 Aug 1;20(15):3945-54
pubmed: 25085789
Eur J Clin Pharmacol. 2015 Mar;71(3):293-302
pubmed: 25567217
J Magn Reson Imaging. 1999 Sep;10(3):223-32
pubmed: 10508281