Everything the clinician needs to know about evidence-based anticoagulation in pregnancy.
Anticoagulants
/ administration & dosage
Blood Coagulation
/ drug effects
Delivery, Obstetric
/ adverse effects
Disease Management
Drug Hypersensitivity
/ etiology
Evidence-Based Medicine
Female
Humans
Hypersensitivity, Delayed
/ etiology
Pregnancy
Pregnancy Complications, Hematologic
/ blood
Pregnancy Outcome
Anticoagulation
Evidence-based
Postpartum period
Pregnancy
Prophylaxis
Safety
Thrombophilia
Thrombosis
Journal
Blood reviews
ISSN: 1532-1681
Titre abrégé: Blood Rev
Pays: England
ID NLM: 8708558
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
23
02
2018
revised:
25
07
2018
accepted:
03
08
2018
pubmed:
16
8
2018
medline:
26
4
2019
entrez:
16
8
2018
Statut:
ppublish
Résumé
Pregnancy is a hemostatic challenge: women are prone to thromboembolism during their pregnancy and at the same time, especially during delivery, there is substantial risk of bleeding. Pregnant women are often excluded from randomized controlled trials, and high quality evidence regarding optimal anticoagulant management is thus lacking. Anticoagulants are being used in pregnancy for prevention and treatment of various pregnancy complications such as thrombotic events, preeclampsia and pregnancy loss. When anticoagulant therapy is necessary, special attention should be given to both woman and unborn child. In this review, we aim to 1) provide an overview of safe anticoagulant use in pregnancy, 2) discuss treatment goals in pregnancy, and 3) summarize the evidence available to guide decision making for frequently encountered clinical dilemmas in this field.
Identifiants
pubmed: 30107951
pii: S0268-960X(18)30020-1
doi: 10.1016/j.blre.2018.08.001
pii:
doi:
Substances chimiques
Anticoagulants
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
82-97Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.