Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome.
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
received:
06
04
2018
accepted:
02
08
2018
pubmed:
17
8
2018
medline:
15
11
2019
entrez:
17
8
2018
Statut:
ppublish
Résumé
The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.
Identifiants
pubmed: 30113672
pii: 5064749
doi: 10.1093/infdis/jiy466
pmc: PMC6284544
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
26-30Subventions
Organisme : NIAID NIH HHS
ID : P01 AI106695
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001876
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001877
Pays : United States
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