Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
13
02
2018
accepted:
04
06
2018
revised:
14
05
2018
pubmed:
18
8
2018
medline:
1
4
2021
entrez:
18
8
2018
Statut:
ppublish
Résumé
Family studies have shown an aggregation of suicidal behavior in families. Yet, molecular studies are needed to identify loci accounting for genetic heritability. We conducted a genome-wide association study and estimated single nucleotide polymorphisms (SNP) heritability for a suicide attempt. In a case-cohort study, national data on all individuals born in Denmark after 1981 and diagnosed with severe mental disorders prior to 2013 (n = 57,377) and individuals from the general population (n = 30,000) were obtained. After quality control, the sample consisted of 6024 cases with an incidence of suicide attempt and 44,240 controls with no record of a suicide attempt. Suggestive associations between SNPs, rs6880062 (p-value: 5.4 × 10
Identifiants
pubmed: 30116032
doi: 10.1038/s41380-018-0218-y
pii: 10.1038/s41380-018-0218-y
pmc: PMC7515833
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2410-2421Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM104400
Pays : United States
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