In-hospital post-transplant acute hepatitis A viral (HAV) infection in a liver transplant recipient who was HAV seropositive pre-transplant.
Acute Disease
Diagnosis, Differential
Hepatitis A
/ epidemiology
Hepatitis A Virus, Human
/ immunology
Humans
Immunoglobulin G
/ immunology
Immunoglobulin M
/ immunology
Immunosuppression Therapy
/ adverse effects
Liver
/ chemistry
Liver Transplantation
/ adverse effects
Male
Middle Aged
Palliative Care
/ methods
Treatment Outcome
Vaccination
/ standards
Vaccination Coverage
/ standards
Acute hepatitis
hepatitis A vaccination
hepatitis A viral infection
immunosuppression
liver transplant
Journal
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
ISSN: 1998-4049
Titre abrégé: Saudi J Gastroenterol
Pays: India
ID NLM: 9516979
Informations de publication
Date de publication:
Historique:
pubmed:
18
8
2018
medline:
5
4
2019
entrez:
18
8
2018
Statut:
ppublish
Résumé
Acute hepatitis A viral (HAV) infection is rare in the liver transplant population due to recommended pre-transplant vaccinations. We report a case of acute hepatitis A infection in a liver transplant recipient. This individual had immunity to hepatitis A with protective IgG antibodies and presented with abnormal liver biochemistry in the post-transplant in-patient setting. Hepatitis A infection was confirmed by positive HAV IgM whereas other etiologies, including acute cellular rejection, were ruled out by laboratory tests and liver biopsies. He was treated conservatively with supportive care and liver enzymes recovered to normal baseline. Despite adequate pre-transplant immunity, in the post-transplant setting there may be loss of protective immunity due to profound immunosuppression and hence hepatitis A should remain an important differential diagnosis in the setting of acute hepatitis.
Identifiants
pubmed: 30117491
pii: 239025
doi: 10.4103/sjg.SJG_230_18
pmc: PMC6373217
doi:
Substances chimiques
Immunoglobulin G
0
Immunoglobulin M
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
67-70Déclaration de conflit d'intérêts
None
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