Acute Ethanol Exposure Promotes Autophagy-Lysosome Pathway-Dependent ASIC1a Protein Degradation and Protects Against Acidosis-Induced Neurotoxicity.
Acid Sensing Ion Channels
/ metabolism
Acidosis
/ complications
Animals
Apoptosis
/ drug effects
Autophagy
/ drug effects
Calcium
/ metabolism
Cyclic AMP-Dependent Protein Kinases
/ metabolism
Enzyme Activation
/ drug effects
Ethanol
/ adverse effects
Ion Channel Gating
/ drug effects
Lysosomes
/ drug effects
MAP Kinase Signaling System
/ drug effects
Mice
Neurons
/ drug effects
Neurotoxicity Syndromes
/ etiology
Proteolysis
/ drug effects
Sodium Channels
/ metabolism
ASICs
Autophagy
Ethanol
Ischemia
Neuroprotection
Neurotoxicity
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
04
05
2018
accepted:
31
07
2018
pubmed:
19
8
2018
medline:
21
8
2019
entrez:
19
8
2018
Statut:
ppublish
Résumé
Tissue acidosis is a common feature of brain ischemia which causes neuronal injury. Activation of acid-sensing ion channel 1a (ASIC1a) plays an important role in acidosis-mediated neurotoxicity. Acute ethanol administration has been shown to provide neuroprotective effects during ischemic stroke, but the precise mechanisms have yet to be determined. In this study, we investigated the effect of ethanol on the activity/expression of ASIC1a channels and acidosis-induced neurotoxicity. We showed that acute treatment of neuronal cells with ethanol for more than 3 h could reduce ASIC1a protein expression, ASIC currents, and acid-induced [Ca
Identifiants
pubmed: 30120732
doi: 10.1007/s12035-018-1289-0
pii: 10.1007/s12035-018-1289-0
pmc: PMC6378129
mid: NIHMS1504184
doi:
Substances chimiques
Acid Sensing Ion Channels
0
Sodium Channels
0
Ethanol
3K9958V90M
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Pagination
3326-3340Subventions
Organisme : National Institutes of Health
ID : S21MD000101
Organisme : National Natural Science Foundation of China
ID : No. 81672127
Organisme : NIMHD NIH HHS
ID : S21 MD000101
Pays : United States
Organisme : National Institutes of Health
ID : R01NS104349
Organisme : NINDS NIH HHS
ID : R01 NS104349
Pays : United States
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