Sleep duration and psychotic experiences in patients at risk of psychosis: A secondary analysis of the EDIE-2 trial.
At risk
Longitudinal
Psychosis
Sleep
Journal
Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
18
05
2018
revised:
06
08
2018
accepted:
07
08
2018
pubmed:
20
8
2018
medline:
5
3
2020
entrez:
20
8
2018
Statut:
ppublish
Résumé
Sleep disturbance is common among individuals at risk of psychosis, yet few studies have investigated the relationship between sleep disturbance and clinical trajectory. The Early Detection and Intervention Evaluation (EDIE-2) trial provides longitudinal data on sleep duration and individual psychotic experiences from a cohort of individuals at risk of psychosis, which this study utilises in an opportunistic secondary analysis. Shorter and more variable sleep was hypothesised to be associated with more severe psychotic experiences and lower psychological wellbeing. Mixed effect models were used to test sleep duration and range as predictors of individual psychotic experiences and psychological wellbeing over the 12-24 months (with assessments every 3 months) in 160 participants. Shorter sleep duration was associated with more severe delusional ideas and hallucinations cross-sectionally and longitudinally. The longitudinal relationships did not remain significant after conservative controls were added for the previous severity of psychotic experiences. No significant relationships were found between the sleep variables and other psychotic experiences (e.g. cognitive disorganisation), or psychological wellbeing. The results support a relationship between shorter sleep duration and delusional ideas and hallucinations. Future studies should focus on improving sleep disturbance measurement, and test whether treating sleep improves clinical trajectory in the at-risk group.
Identifiants
pubmed: 30121185
pii: S0920-9964(18)30498-5
doi: 10.1016/j.schres.2018.08.006
pmc: PMC6406020
pii:
doi:
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
326-333Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0500264
Pays : United Kingdom
Organisme : Department of Health
ID : RP-2014-05-003
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098461/Z/12/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
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