High proliferation rate and TNM stage but not histomorphological subtype are independent prognostic markers for overall survival in papillary renal cell carcinoma.
Histopathology
Immunohistochemistry
MIB1
Papillary renal cell carcinoma
Renal cell carcinoma
Subtype
Journal
Human pathology
ISSN: 1532-8392
Titre abrégé: Hum Pathol
Pays: United States
ID NLM: 9421547
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
18
05
2018
revised:
02
08
2018
accepted:
04
08
2018
pubmed:
20
8
2018
medline:
16
11
2019
entrez:
20
8
2018
Statut:
ppublish
Résumé
Papillary renal cell carcinoma (PRCC) is currently divided in 2 subtypes. We reviewed a large cohort of PRCC and correlated subtype, morphological features and diagnostic marker expression with overall survival (OS) to uncover differences between the 2 subtypes. Three hundred seventy-six renal tumors initially diagnosed as PRCC with clinical and survival data were collected from the participating centers. Two hundred forty-six tumors were classified as PRCC1 (65.4%) and 130 as PRCC2 (34.6%) and graded according to the 2016 World Health Organization/International Society of Urological Pathology grading system. Morphological features (abundant cytoplasm, necrosis, fibrous stroma, foamy macrophages and psammoma bodies) were noted. Immunohistochemical stains (MIB1, p53, Racemase, EMA, CK7, CK20, E-Cadherin) were performed using tissue microarrays. χ
Identifiants
pubmed: 30121370
pii: S0046-8177(18)30311-3
doi: 10.1016/j.humpath.2018.08.006
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
212-223Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.