Production of certified reference materials for the sports doping control of the REV-ERB agonist SR9009.
SR9009
certified reference materials
human metabolites
purity assignment
synthesis
Journal
Drug testing and analysis
ISSN: 1942-7611
Titre abrégé: Drug Test Anal
Pays: England
ID NLM: 101483449
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
18
06
2018
revised:
16
07
2018
accepted:
10
08
2018
pubmed:
22
8
2018
medline:
2
7
2019
entrez:
22
8
2018
Statut:
ppublish
Résumé
Two human metabolites of the REV-ERB agonist SR9009, identified by researchers with an interest in sports doping control, have been synthesized and assessed for purity. The synthesis employed was a modification of published procedures for the parent SR9009, careful attention to the purification of intermediates and the final product ensuring materials of the highest purity were available for certification. For each candidate material impurities of related structure were identified and quantified as a relative mass fraction using high performance liquid chromatography-ultraviolet (HPLC-UV) detection and proton nuclear magnetic resonance (
Substances chimiques
Pyrrolidines
0
SR9009
0
Thiophenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
257-266Subventions
Organisme : Partnership for Clean Competition
ID : 2015 230000 NMI R215 Davies
Informations de copyright
© 2018 Commonwealth of Australia. Drug Testing and Analysis © 2018 John Wiley & Sons, Ltd.