Association of Changes in Effusion-Synovitis With Progression of Cartilage Damage Over Eighteen Months in Patients With Osteoarthritis and Meniscal Tear.
Aged
Cartilage, Articular
/ diagnostic imaging
Disease Progression
Female
Humans
Knee Joint
/ diagnostic imaging
Magnetic Resonance Imaging
Male
Meniscectomy
Middle Aged
Osteoarthritis, Knee
/ diagnostic imaging
Physical Therapy Modalities
Synovitis
/ diagnostic imaging
Tibial Meniscus Injuries
/ diagnostic imaging
Journal
Arthritis & rheumatology (Hoboken, N.J.)
ISSN: 2326-5205
Titre abrégé: Arthritis Rheumatol
Pays: United States
ID NLM: 101623795
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
14
03
2018
accepted:
05
07
2018
pubmed:
23
8
2018
medline:
2
11
2019
entrez:
23
8
2018
Statut:
ppublish
Résumé
Synovitis is a feature of knee osteoarthritis (OA) and meniscal tear and has been associated with articular cartilage damage. This study was undertaken to examine the associations of baseline effusion-synovitis and changes in effusion-synovitis with changes in cartilage damage in a cohort with OA and meniscal tear. We analyzed data from the Meniscal Tear in Osteoarthritis Research (MeTeOR) trial of surgery versus physical therapy for treatment of meniscal tear. We performed semiquantitative grading of effusion-synovitis and cartilage damage on magnetic resonance imaging, and dichotomized effusion-synovitis as none/small (minimal) and medium/large (extensive). We assessed the association of baseline effusion-synovitis and changes in effusion-synovitis with changes in cartilage damage size and depth over 18 months, using Poisson regression models. Analyses were adjusted for patient demographic characteristics, treatment, and baseline cartilage damage. We analyzed 221 participants. Over 18 months, effusion-synovitis was persistently minimal in 45.3% and persistently extensive in 21.3% of the patients. The remaining 33.5% of the patients had minimal synovitis on one occasion and extensive synovitis on the other. In adjusted analyses, patients with extensive effusion-synovitis at baseline had a relative risk (RR) of progression of cartilage damage depth of 1.7 (95% confidence interval [95% CI] 1.0-2.7). Compared to those with persistently minimal effusion-synovitis, those with persistently extensive effusion-synovitis had a significantly increased risk of progression of cartilage damage depth (RR 2.0 [95% CI 1.1-3.4]). Our findings indicate that the presence of extensive effusion-synovitis is associated with subsequent progression of cartilage damage over 18 months. The persistence of extensive effusion-synovitis over time is associated with the greatest risk of concurrent cartilage damage progression.
Identifiants
pubmed: 30133187
doi: 10.1002/art.40660
pmc: PMC6310094
mid: NIHMS980548
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-81Subventions
Organisme : NIAMS NIH HHS
ID : K24 AR057827
Pays : United States
Organisme : NIAMS NIH HHS
ID : P60 AR047782
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR055885
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR055557
Pays : United States
Investigateurs
Robert H Brophy
(RH)
Bruce A Levy
(BA)
Robert G Marx
(RG)
Mathew Matava
(M)
Clare Safran-Norton
(C)
Kurt P Spindler
(KP)
Michael Stuart
(M)
Diane L Dahm
(DL)
Rick Wright
(R)
Informations de copyright
© 2018, American College of Rheumatology.
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