Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels.
GIRK channel
GIRK2
Kir3
activator
high-throughput screening
ion channel
modulator
small molecule
thallium flux assay
whole-cell patch-clamp electrophysiology
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
16 01 2019
16 01 2019
Historique:
pubmed:
24
8
2018
medline:
19
2
2020
entrez:
24
8
2018
Statut:
ppublish
Résumé
G protein-gated, inwardly rectifying, potassium (GIRK) channels are important regulators of cellular excitability throughout the body. GIRK channels are heterotetrameric and homotetrameric combinations of the K
Identifiants
pubmed: 30136838
doi: 10.1021/acschemneuro.8b00287
pmc: PMC6528656
mid: NIHMS991287
doi:
Substances chimiques
G Protein-Coupled Inwardly-Rectifying Potassium Channels
0
Pyrazines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
358-370Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM007628
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007347
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA068485
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM065086
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH099363
Pays : United States
Organisme : NIH HHS
ID : S10 OD021734
Pays : United States
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