Membranous Nephropathy with Crescent after Hematopoietic Cell Transplantation.
C4d positivity on peritubular capillaries
crescent
graft-versus-host disease
membranous nephropathy
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
01 Jan 2019
01 Jan 2019
Historique:
pubmed:
28
8
2018
medline:
16
2
2019
entrez:
28
8
2018
Statut:
ppublish
Résumé
A 44-year-old man who received allogenic hematopoietic stem cell transplantation after being diagnosed with acute myeloid leukemia developed nephrosis when the dose of tacrolimus was tapered. A renal biopsy showed the granular deposition of immunoglobulin G in the glomerular basement membrane and subepithelial electron-dense deposits, crescent formation, C4d-positive staining of the peritubular capillary, and subendothelial swelling, suggesting that the main pathological diagnosis was membranous nephropathy and that chronic graft-versus-host disease played a role in the etiology of nephrosis. We herein report a case of membranous nephropathy with various pathological findings. C4d deposition suggests complement activation and the involvement of humoral factors.
Identifiants
pubmed: 30146584
doi: 10.2169/internalmedicine.1251-18
pmc: PMC6367071
doi:
Substances chimiques
Complement C4b
80295-50-7
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
91-96Références
Curr Biol. 2001 Nov 13;11(22):1805-9
pubmed: 11719225
Kidney Int. 2003 Mar;63(3):1164-77
pubmed: 12631105
Clin J Am Soc Nephrol. 2006 Jul;1(4):685-94
pubmed: 17699273
Am J Physiol Renal Physiol. 2010 Mar;298(3):F702-11
pubmed: 20007346
Haematologica. 2010 Nov;95(11):1811-3
pubmed: 21037328
Pathol Int. 2011 Jan;61(1):34-41
pubmed: 21166941
Pathol Int. 2011 Sep;61(9):518-27
pubmed: 21884301
Am J Med Sci. 2013 Jul;346(1):32-7
pubmed: 23103439
Mod Pathol. 2013 May;26(5):709-15
pubmed: 23196797
Am J Transplant. 2014 Feb;14(2):272-83
pubmed: 24472190
Am J Kidney Dis. 2014 Jul;64(1):66-73
pubmed: 24709471
Am J Kidney Dis. 2014 Dec;64(6):987-93
pubmed: 25304985
Curr Opin Nephrol Hypertens. 2015 May;24(3):231-8
pubmed: 25887901
Hum Pathol. 2016 Apr;50:187-94
pubmed: 26997455
N Engl J Med. 2016 Jun 9;374(23):2256-67
pubmed: 27276563