Are treatment supporters relevant in long-term Antiretroviral Therapy (ART) adherence? Experiences from a long-term ART cohort in Uganda.
ART adherence
Treatment supporters
Uganda
long-term ART
viral load
Journal
Global public health
ISSN: 1744-1706
Titre abrégé: Glob Public Health
Pays: England
ID NLM: 101256323
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
pubmed:
28
8
2018
medline:
10
1
2020
entrez:
28
8
2018
Statut:
ppublish
Résumé
This study aimed to understand the relevance of treatment supporters in adherence among people living with HIV taking Anti-retroviral therapy (ART) for more than five years in Uganda. In-depth interviews were conducted with 50 participants (28 women and 22 men) of the Complications of Long-Term ART (CoLTART) cohort with experience of at least five years on ART in Uganda. Participants were stratified by line of ART regimen and viral loads of less or above 1000 copies/ml. Data were analyzed thematically. Many participants felt that a treatment supporter was most useful at the beginning of therapy before individuals get used to the drugs or when they are still weak. However, this did not reflect treatment outcomes, as many individuals without treatment supporters had failed on first line ART regimens and were switched to second line ART. Those who were still on first line had viral loads of ≥1000 copies/ml. There was a preference for female treatment supporters, many of who were persistent in their supportive role. Treatment supporters remain important in adherence to long-term ART. HIV-care providers need to encourage the involvement of a treatment supporter for individuals taking ART long-term.
Sections du résumé
BACKGROUND
This study aimed to understand the relevance of treatment supporters in adherence among people living with HIV taking Anti-retroviral therapy (ART) for more than five years in Uganda.
METHODS
In-depth interviews were conducted with 50 participants (28 women and 22 men) of the Complications of Long-Term ART (CoLTART) cohort with experience of at least five years on ART in Uganda. Participants were stratified by line of ART regimen and viral loads of less or above 1000 copies/ml. Data were analyzed thematically.
RESULTS
Many participants felt that a treatment supporter was most useful at the beginning of therapy before individuals get used to the drugs or when they are still weak. However, this did not reflect treatment outcomes, as many individuals without treatment supporters had failed on first line ART regimens and were switched to second line ART. Those who were still on first line had viral loads of ≥1000 copies/ml. There was a preference for female treatment supporters, many of who were persistent in their supportive role.
CONCLUSION
Treatment supporters remain important in adherence to long-term ART. HIV-care providers need to encourage the involvement of a treatment supporter for individuals taking ART long-term.
Identifiants
pubmed: 30146972
doi: 10.1080/17441692.2018.1514418
pmc: PMC6334778
doi:
Substances chimiques
Anti-Retroviral Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
469-480Subventions
Organisme : Medical Research Council
ID : MC_U950080928
Pays : United Kingdom
Références
J Int AIDS Soc. 2016 Nov 30;19(1):21141
pubmed: 27914185
AIDS Care. 2011 Feb;23(2):231-6
pubmed: 21259136
AIDS Res Treat. 2016;2016:9124541
pubmed: 27092271
Trop Med Int Health. 2007 Oct;12(10):1191-8
pubmed: 17956501
AIDS Care. 2006 Nov;18(8):895-903
pubmed: 17012078
AIDS Behav. 2011 Nov;15(8):1795-802
pubmed: 21424272
Glob Public Health. 2015;10(10):1185-200
pubmed: 25947225
Health Transit Rev. 1996 Apr;6(1):49-56
pubmed: 10163411
J Assoc Nurses AIDS Care. 2014 Sep-Oct;25(5):405-13
pubmed: 24508174
AIDS Care. 2011 Jun;23(6):657-62
pubmed: 21347887
J Acquir Immune Defic Syndr. 2006 Dec 1;43 Suppl 1:S127-33
pubmed: 17133196
AIDS Care. 2018 Jul;30(7):879-887
pubmed: 29463099
AIDS. 2014 Jan 14;28(2):181-186
pubmed: 24361679
AIDS Behav. 2011 Oct;15(7):1429-36
pubmed: 20632081
J Int AIDS Soc. 2017 Oct;20(2):
pubmed: 29052344
PLoS One. 2013 Oct 11;8(10):e78243
pubmed: 24147126
AIDS Behav. 2017 Jun;21(6):1755-1767
pubmed: 27582088
PLoS One. 2015 Jun 03;10(6):e0126810
pubmed: 26039733
Soc Sci Med. 2018 Sep;213:72-84
pubmed: 30059900
BMC Res Notes. 2016 Dec 23;9(1):515
pubmed: 28010730
AIDS Res Ther. 2017 May 4;14:26
pubmed: 28484508
AIDS Care. 2010;22 Suppl 1:35-43
pubmed: 20680859
AIDS Care. 1993;5(1):117-22
pubmed: 8461355
AIDS Care. 2009 Nov;21(11):1412-9
pubmed: 20024718
AIDS Care. 2011 Oct;23(10):1264-73
pubmed: 21726159
PLoS Med. 2009 Jan 27;6(1):e11
pubmed: 19175285
J Acquir Immune Defic Syndr. 2015 Sep 1;70(1):75-82
pubmed: 26039929
Bull World Health Organ. 2015 Jul 1;93(7):457-67
pubmed: 26170503
J Int AIDS Soc. 2017 Jan 12;20(1):21188
pubmed: 28364566
Health Justice. 2015 Dec 18;3:18
pubmed: 26709367
AIDS Behav. 2012 Jul;16(5):1308-15
pubmed: 21947835
Curr HIV/AIDS Rep. 2014 Dec;11(4):423-33
pubmed: 25304006
Lancet HIV. 2014 Dec;1(3):e104-11
pubmed: 26424119
PLoS One. 2014 May 14;9(5):e97353
pubmed: 24828585
PLoS One. 2013;8(2):e55747
pubmed: 23418455
Lancet. 2010 Jan 9;375(9709):123-31
pubmed: 20004464
AIDS Behav. 2015 Apr;19(4):601-11
pubmed: 25342151
J Int AIDS Soc. 2014 Sep 18;17:19160
pubmed: 25239379
Curr Opin HIV AIDS. 2010 Jan;5(1):70-7
pubmed: 20046150
Afr J Psychiatry (Johannesbg). 2010 Mar;13(1):43-51
pubmed: 20428598
Lancet HIV. 2017 Jul;4(7):e295-e302
pubmed: 28479492
PLoS One. 2016 Nov 29;11(11):e0167492
pubmed: 27898736
Trop Med Int Health. 2015 Jul;20(7):903-13
pubmed: 25754063
BMC Public Health. 2006 Nov 20;6:284
pubmed: 17116252
AIDS Care. 2017 Dec;29(12):1473-1479
pubmed: 28436276
Afr Health Sci. 2013 Jun;13(2):311-9
pubmed: 24235929
AIDS Patient Care STDS. 2015 Jun;29(6):354-64
pubmed: 25825814
Qual Health Res. 2009 Dec;19(12):1744-54
pubmed: 19949223
AIDS Patient Care STDS. 2013 Feb;27(2):96-102
pubmed: 23373664
J Int AIDS Soc. 2013 Jun 30;16:18757
pubmed: 23819908
J Int AIDS Soc. 2012;15(2):17429
pubmed: 22905360
Afr J AIDS Res. 2018 Sep;17(3):217-225
pubmed: 30132397
BMC Health Serv Res. 2017 May 9;17(1):341
pubmed: 28486980