Unmet Needs in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms (WHO G3).
Neuroendocrine carcinoma
Neuroendocrine neoplasm
Neuroendocrine tumor
Journal
Neuroendocrinology
ISSN: 1423-0194
Titre abrégé: Neuroendocrinology
Pays: Switzerland
ID NLM: 0035665
Informations de publication
Date de publication:
2019
2019
Historique:
received:
26
06
2018
accepted:
27
08
2018
pubmed:
29
8
2018
medline:
18
12
2019
entrez:
29
8
2018
Statut:
ppublish
Résumé
Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are classified based on morphology and graded based on their proliferation rate as either well-differentiated low-grade (G1 to G2) neuroendocrine tumors (NET) or poorly differentiated high-grade (G3) neuroendocrine carcinomas (NEC). Recently, a new subgroup of well-differentiated high-grade pancreatic tumors (NET G3) has been defined. The GEP NEN G3 group consisting of both NEC and NET G3 has recently been shown to be a quite heterogeneous patient group concerning prognosis and treatment benefit, depending on factors such as the primary tumor site, differentiation, proliferation rate, and molecular alterations. In this review we discuss the existing data on diagnostics, treatment, and biomarkers in this patient group, the unmet needs, and the future perspectives.
Identifiants
pubmed: 30153658
pii: 000493318
doi: 10.1159/000493318
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
54-62Investigateurs
Detlef Bartsch
(D)
Rudolf Arnold
(R)
Eric Baudin
(E)
Lisa Bodei
(L)
Ivan Borbath
(I)
Jaume Capdevila
(J)
Martyn Caplin
(M)
Jie Chen
(J)
Frederico Costa
(F)
Anne Couvelard
(A)
Jaroslaw Ćwikła
(J)
Philippa Davies
(P)
Herder de
(H)
Massimo Falconi
(M)
Jenny Falkerby
(J)
Nicola Fazio
(N)
Diego Ferone
(D)
Andrea Frilling
(A)
Rocio Garcia-Carbonero
(R)
Simona Glasberg
(S)
Vera Gorbunova
(V)
Ashley Grossman
(A)
Dieter Hörsch
(D)
Robert Jensen
(R)
Gregory Kaltsas
(G)
Günter Klöppel
(G)
Ulrich Knigge
(U)
Beata Kos-Kudła
(B)
Guenter Krejs
(G)
Eric Krenning
(E)
Matthew Kulke
(M)
Steven Lamberts
(S)
van Nieveen
(V)
Juan O'Connor
(J)
Dermot O'Toole
(D)
Ulrich-Frank Pape
(UF)
Stefano Partelli
(S)
Marianne Pavel
(M)
Marc Peeters
(M)
John Ramage
(J)
Nicholas Reed
(N)
Guido Rindi
(G)
Anja Rinke
(A)
Philippe Ruszniewski
(P)
Halfdan Sorbye
(H)
Anders Sundin
(A)
Jean-Yves Scoazec
(JY)
Babs Taal
(B)
Janson Tiensuu
(J)
Christos Toumpanakis
(C)
Juan Valle
(J)
Marie-Pierre Vullierme
(MP)
Staffan Welin
(S)
Bertram Wiedenmann
(B)
Informations de copyright
© 2018 S. Karger AG, Basel.