Unmet Medical Needs in Metastatic Lung and Digestive Neuroendocrine Neoplasms.


Journal

Neuroendocrinology
ISSN: 1423-0194
Titre abrégé: Neuroendocrinology
Pays: Switzerland
ID NLM: 0035665

Informations de publication

Date de publication:
2019
Historique:
received: 02 07 2018
accepted: 27 08 2018
pubmed: 29 8 2018
medline: 18 12 2019
entrez: 29 8 2018
Statut: ppublish

Résumé

Unmet medical needs are not infrequent in oncology, and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade, and, currently, a new WHO classification is being implemented and several treatment options are available in the metastatic setting after the results of prospective phase III clinical trials. However, several questions are still unanswered, and decisions in our daily clinical practice should be made with limited evidence. In the 2016 meeting of the advisory board of the European Neuroendocrine Tumor Society (ENETS), the main unmet medical needs in the metastatic NENs setting were deeply discussed, and several proposals to try to solve them are presented in this article, including biomarkers, imaging, and therapy.

Identifiants

pubmed: 30153686
pii: 000493319
doi: 10.1159/000493319
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

18-25

Investigateurs

Detlef Bartsch (D)
Rudolf Arnold (R)
Eric Baudin (E)
Lisa Bodei (L)
Ivan Borbath (I)
Jaume Capdevila (J)
Martyn Caplin (M)
Jie Chen (J)
Frederico Costa (F)
Anne Couvelard (A)
Jaroslaw Ćwikła (J)
Philippa Davies (P)
Herder de (H)
Massimo Falconi (M)
Jenny Falkerby (J)
Nicola Fazio (N)
Diego Ferone (D)
Andrea Frilling (A)
Rocio Garcia-Carbonero (R)
Simona Glasberg (S)
Vera Gorbunova (V)
Ashley Grossman (A)
Dieter Hörsch (D)
Robert Jensen (R)
Gregory Kaltsas (G)
Günter Klöppel (G)
Ulrich Knigge (U)
Beata Kos-Kudła (B)
Guenter Krejs (G)
Eric Krenning (E)
Matthew Kulke (M)
Steven Lamberts (S)
van Nieveen (V)
Juan O'Connor (J)
Dermot O'Toole (D)
Ulrich-Frank Pape (UF)
Stefano Partelli (S)
Marianne Pavel (M)
Marc Peeters (M)
John Ramage (J)
Nicholas Reed (N)
Guido Rindi (G)
Anja Rinke (A)
Philippe Ruszniewski (P)
Halfdan Sorbye (H)
Anders Sundin (A)
Jean-Yves Scoazec (JY)
Babs Taal (B)
Janson Tiensuu (J)
Christos Toumpanakis (C)
Juan Valle (J)
Marie-Pierre Vullierme (MP)
Staffan Welin (S)
Bertram Wiedenmann (B)

Informations de copyright

©2018 S. Karger AG, Basel.

Auteurs

Jaume Capdevila (J)

Vall Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spainjcapdevila@vhio.net.

Lisa Bodei (L)

Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Philippa Davies (P)

Neuroendocrine Tumour Unit, Royal Free Hospital, London, United Kingdom.

Vera Gorbounova (V)

Department of Oncology, Institution of Russian Academy of Medical Sciences, Moscow, Russian Federation.

Robert T Jensen (RT)

National Institutes of Health, Bethesda, Maryland, USA.

Ulrich P Knigge (UP)

Department of Surgery, University of Copenhagen, Copenhagen, Denmark.

Guenter J Krejs (GJ)

Medical University of Graz, Graz, Austria.

Eric Krenning (E)

Cyclotron Rotterdam BV, Erasmus MC, Rotterdam, The Netherlands.

Juan Manuel O'Connor (JM)

Alexander Fleming Institute, Caba, Argentina.

Marc Peeters (M)

Department of Oncology, Antwerp University Hospital, Antwerp, Belgium.

Guido Rindi (G)

Fondazione Policlinico Universitario A. Gemelli IRCCS Roma-Università Cattolica del Sacro Cuore, Rome, Italy.

Ramon Salazar (R)

Catalan Institute of Oncology, Oncobell Program, IDIBELL, Cerca, Ciberonc, Barcelona, Spain.

Marie-Pierre Vullierme (MP)

Radiology Department, Beaujon Hôpital Assistance Publique, Paris, France.

Marianne E Pavel (ME)

Friedrich-Alexander Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.

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Classifications MeSH