Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma.
dogs
immunotherapy
macrophages
osteosarcoma
tumour microenvironment
Journal
Veterinary and comparative oncology
ISSN: 1476-5829
Titre abrégé: Vet Comp Oncol
Pays: England
ID NLM: 101185242
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
24
07
2018
revised:
20
08
2018
accepted:
21
08
2018
pubmed:
30
8
2018
medline:
28
2
2019
entrez:
30
8
2018
Statut:
ppublish
Résumé
Immunotherapeutic strategies have shown promise for the treatment of canine osteosarcoma (cOSA). Very little is known about the immune microenvironment within cOSA, however, limiting our ability to identify potential immune targets and biomarkers of therapeutic response. We therefore prospectively assessed the disease-free interval (DFI) and overall survival time (ST) of 30 dogs with cOSA treated with amputation and six doses of adjuvant carboplatin. We then quantified lymphocytic (CD3+, FOXP3+) and macrophage (CD204+) infiltrates within the primary tumours of this cohort using immunohistochemistry, and evaluated their association with outcome. Overall, the median DFI and ST were 392 and 455 days, respectively. The median number of CD3+ and FOXP3+ infiltrates were 45.8 cells/mm
Identifiants
pubmed: 30156029
doi: 10.1111/vco.12444
pmc: PMC6363827
mid: NIHMS987024
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
49-60Subventions
Organisme : American Kennel Club Canine Health Foundation
ID : Clinican-Scientist Fellowship Program
Organisme : NCI NIH HHS
ID : P30 CA093373
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA224166
Pays : United States
Organisme : Center for Companion Animal Health, School of Veterinary Medicine, University of California-Davis
Organisme : National Cancer Institute
ID : P30CA093373
Organisme : National Cancer Institute
ID : U01CA224166-01
Informations de copyright
© 2018 John Wiley & Sons Ltd.
Références
Cancer Biother Radiopharm. 1999 Apr;14(2):121-8
pubmed: 10850295
Clin Cancer Res. 2002 Jul;8(7):2406-12
pubmed: 12114446
Cancer Chemother Pharmacol. 2002 Aug;50(2):131-6
pubmed: 12172978
J Vet Intern Med. 2003 Mar-Apr;17(2):199-205
pubmed: 12683621
Blood. 2004 Oct 15;104(8):2224-34
pubmed: 15231578
J Vet Intern Med. 2004 Jul-Aug;18(4):540-4
pubmed: 15320595
Ann Surg Oncol. 2005 Dec;12(12):1073-83
pubmed: 16252138
J Am Anim Hosp Assoc. 2005 Nov-Dec;41(6):382-7
pubmed: 16267062
J Am Vet Med Assoc. 1992 Jun 15;200(12):2005-8
pubmed: 1639715
Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6659-64
pubmed: 16617117
J Immunol. 2006 Nov 15;177(10):7303-11
pubmed: 17082649
Eur J Immunol. 2007 Jan;37(1):129-38
pubmed: 17154262
J Clin Oncol. 2008 Feb 1;26(4):633-8
pubmed: 18235123
Semin Cancer Biol. 2008 Oct;18(5):349-55
pubmed: 18467122
J Am Vet Med Assoc. 2008 May 15;232(10):1504-10
pubmed: 18479240
J Exp Med. 2008 Sep 1;205(9):2125-38
pubmed: 18725522
J Am Anim Hosp Assoc. 2009 Jan-Feb;45(1):33-8
pubmed: 19122062
J Vet Intern Med. 1991 Jul-Aug;5(4):205-10
pubmed: 1941754
Blood. 2009 Aug 20;114(8):1537-44
pubmed: 19423728
Cancer Immunol Immunother. 2010 Mar;59(3):367-78
pubmed: 19701748
Oncogene. 2010 Jul 22;29(29):4121-9
pubmed: 20498631
J Vet Intern Med. 2010 Sep-Oct;24(5):1118-23
pubmed: 20666983
J Vet Intern Med. 2010 Nov-Dec;24(6):1439-44
pubmed: 20840314
J Am Vet Med Assoc. 2011 Jan 15;238(2):195-206
pubmed: 21235373
Cancer Res. 2011 Feb 15;71(4):1263-71
pubmed: 21303976
Clin Cancer Res. 2011 Apr 15;17(8):2110-9
pubmed: 21372215
Immunotherapy. 2011 Oct;3(10):1235-51
pubmed: 21995574
Ann Oncol. 2012 Jun;23(6):1607-16
pubmed: 22015453
PLoS One. 2012;7(3):e33274
pubmed: 22428007
Clin Cancer Res. 2012 Jun 1;18(11):3022-9
pubmed: 22510350
Vet Comp Oncol. 2014 Mar;12(1):10-9
pubmed: 22533625
Vet Comp Oncol. 2014 Mar;12(1):20-8
pubmed: 22541038
BMC Vet Res. 2012 May 15;8:56
pubmed: 22587466
Vet Pathol. 2013 Mar;50(2):281-90
pubmed: 22711745
Mol Ther. 2012 Dec;20(12):2234-43
pubmed: 22850679
J Comp Pathol. 2013 Feb;148(2-3):188-96
pubmed: 22901707
J Immunol. 2012 Nov 15;189(10):5029-36
pubmed: 23034170
BMC Vet Res. 2012 Oct 31;8:209
pubmed: 23110794
J Immunol. 2013 Apr 1;190(7):3783-97
pubmed: 23440412
Int J Radiat Oncol Biol Phys. 1990 Jun;18(6):1351-7
pubmed: 2370184
Br J Dermatol. 2014 Jan;170(1):103-9
pubmed: 24116716
Vet Comp Oncol. 2016 Mar;14(1):81-7
pubmed: 24118677
J Vet Intern Med. 2014 Mar-Apr;28(2):554-63
pubmed: 24512451
Biomed Res Int. 2014;2014:130894
pubmed: 24672781
Clin Cancer Res. 2014 Oct 1;20(19):5064-74
pubmed: 24714771
Clin Exp Immunol. 2014 Oct;178(1):1-8
pubmed: 24828133
Cancer Immunol Res. 2014 Jul;2(7):690-698
pubmed: 24866169
Adv Exp Med Biol. 2014;804:307-21
pubmed: 24924182
Immunity. 2014 Jul 17;41(1):49-61
pubmed: 25035953
PLoS One. 2014 Aug 13;9(8):e105027
pubmed: 25119018
Front Immunol. 2014 Oct 07;5:491
pubmed: 25339958
Nature. 2014 Nov 27;515(7528):563-7
pubmed: 25428504
J Immunother Cancer. 2014 Nov 18;2(1):38
pubmed: 25436113
J Immunol. 2015 Apr 1;194(7):3475-86
pubmed: 25725111
J Immunother. 2015 Apr;38(3):96-106
pubmed: 25751499
Int J Clin Exp Med. 2015 Feb 15;8(2):1803-13
pubmed: 25932108
Oncoimmunology. 2015 Apr 02;4(3):e990800
pubmed: 25949908
Oncotarget. 2015 Aug 21;6(24):20204-14
pubmed: 26001293
Vet Pathol. 2016 Jan;53(1):102-12
pubmed: 26173451
Nat Med. 2015 Aug;21(8):938-945
pubmed: 26193342
Cell Mol Life Sci. 2015 Nov;72(21):4111-26
pubmed: 26210152
BMC Cancer. 2015 Oct 17;15:727
pubmed: 26475790
Biomed Res Int. 2015;2015:314620
pubmed: 26583099
Int Immunopharmacol. 2016 May;34:101-106
pubmed: 26938675
Clin Cancer Res. 2016 Sep 1;22(17):4380-90
pubmed: 26994144
NPJ Breast Cancer. 2016;2:null
pubmed: 26998515
J Am Anim Hosp Assoc. 2016 May-Jun;52(3):149-56
pubmed: 27008320
J Natl Cancer Inst. 1989 Jun 21;81(12):935-8
pubmed: 2733037
J Vet Intern Med. 2016 Jul;30(4):1167-78
pubmed: 27338235
Sci Rep. 2016 Jul 26;6:30093
pubmed: 27456063
Clin Sarcoma Res. 2016 Aug 01;6:13
pubmed: 27482375
J Immunol Res. 2016;2016:4757405
pubmed: 27777963
Vet Comp Oncol. 2017 Dec;15(4):1309-1322
pubmed: 27779362
Oncotarget. 2016 Nov 29;7(48):78343-78354
pubmed: 27823976
Cancer Immunol Immunother. 2017 Jan;66(1):119-128
pubmed: 27853827
Innate Immun. 2017 Apr;23(3):228-239
pubmed: 28100085
J Hematol Oncol. 2017 Feb 28;10(1):58
pubmed: 28241846
Vet Comp Oncol. 2017 Dec;15(4):1382-1392
pubmed: 28467670
J Immunother Cancer. 2017 May 16;5:44
pubmed: 28515944
Crit Rev Oncol Hematol. 2017 Aug;116:116-124
pubmed: 28693793
Vet Immunol Immunopathol. 2017 Aug;190:53-56
pubmed: 28778323
Sci Immunol. 2017 Jan 6;2(7):null
pubmed: 28783667
Oncoimmunology. 2017 Aug 24;6(9):e1331193
pubmed: 28932633
Oncotarget. 2017 Dec 4;8(67):111836-111846
pubmed: 29340095
Front Oncol. 2018 Mar 12;8:49
pubmed: 29594035
Vet J. 2018 Apr;234:119-125
pubmed: 29680383
Cancer Med. 2018 Jun;7(6):2654-2664
pubmed: 29733528
J Vet Intern Med. 1988 Oct-Dec;2(4):177-80
pubmed: 3230557
Cancer Biother. 1993 Summer;8(2):137-44
pubmed: 7804354
J Vet Intern Med. 1996 Mar-Apr;10(2):76-81
pubmed: 8683484
Cancer. 1997 Apr 1;79(7):1343-50
pubmed: 9083156
Cancer. 1997 Apr 1;79(7):1409-21
pubmed: 9083164
Clin Cancer Res. 1995 Dec;1(12):1595-601
pubmed: 9815961