Autophagy mediates phosphatidylserine exposure and phagosome degradation during apoptosis through specific functions of GABARAP/LGG-1 and LC3/LGG-2.
None
Apoptosis
LAP process
VPS-39
cell death
embryogenesis
lysosome
phagosome
phosphatidylserine
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
pubmed:
31
8
2018
medline:
7
3
2020
entrez:
31
8
2018
Statut:
ppublish
Résumé
Phagocytosis and macroautophagy/autophagy are 2 processes involved in lysosome-mediated clearance of extracellular and intracellular components, respectively. Recent studies have identified the recruitment of the autophagic protein LC3 during phagocytosis of apoptotic corpses in what is now called LC3-associated phagocytosis (LAP). LAP is a distinct process from autophagy but it relies on some members of the autophagy pathway to allow efficient degradation of the phagocytosed cargo. We investigated whether both LC3/LGG-2 and GABARAP/LGG-1 are involved in phagocytosis of apoptotic corpses during embryonic development of
Identifiants
pubmed: 30160610
doi: 10.1080/15548627.2018.1512452
pmc: PMC6333449
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
LGG-1 protein, C elegans
0
LGG-2 protein, C elegans
0
Microtubule-Associated Proteins
0
Phosphatidylserines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
228-241Références
Cell Death Differ. 2011 May;18(5):817-28
pubmed: 21113143
Cell. 2013 Jul 18;154(2):365-76
pubmed: 23870125
Methods. 2003 Aug;30(4):313-21
pubmed: 12828945
J Toxicol. 2012;2012:546915
pubmed: 22899914
Autophagy. 2013 Dec;9(12):2022-32
pubmed: 24165672
Biol Cell. 2009 Dec 04;102(2):121-32
pubmed: 19807690
Dev Cell. 2006 Jun;10(6):743-57
pubmed: 16740477
Mol Cell. 2012 Nov 9;48(3):329-42
pubmed: 23022382
Nat Cell Biol. 2000 Jul;2(7):415-22
pubmed: 10878806
EMBO J. 2015 Oct 1;34(19):2441-64
pubmed: 26282792
Cell Microbiol. 2011 Jun;13(6):814-35
pubmed: 21447143
Cell Death Differ. 2008 Aug;15(8):1279-90
pubmed: 18369370
Nature. 2012 Aug 9;488(7410):226-30
pubmed: 22801495
Nat Cell Biol. 2011 Oct 16;13(11):1335-43
pubmed: 22002674
Genome Biol. 2011 Jul 27;12(7):226
pubmed: 21867568
Genetics. 2015 Sep;201(1):47-54
pubmed: 26187122
Nat Commun. 2013;4:2726
pubmed: 24225442
Nature. 1998 Oct 29;395(6705):854
pubmed: 9804418
Mol Cell. 2000 Mar;5(3):423-33
pubmed: 10882128
Nat Cell Biol. 2015 Jul;17(7):893-906
pubmed: 26098576
Autophagy. 2013 Feb 1;9(2):138-49
pubmed: 23108454
Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17396-401
pubmed: 21969579
Science. 2013 Jul 26;341(6144):403-6
pubmed: 23845944
Science. 2011 Nov 25;334(6059):1144-7
pubmed: 22033522
Mol Biol Cell. 2007 Aug;18(8):3180-92
pubmed: 17567952
Nature. 2010 Jul 1;466(7302):68-76
pubmed: 20562859
Curr Biol. 2012 Jul 24;22(14):1267-75
pubmed: 22727702
Science. 2003 Nov 28;302(5650):1516-7
pubmed: 14645835
J Vis Exp. 2012 Dec 03;(70):e3995
pubmed: 23242070
Nature. 2007 Dec 20;450(7173):1253-7
pubmed: 18097414
Immunity. 2012 Dec 14;37(6):986-997
pubmed: 23219390
Dev Biol. 1983 Nov;100(1):64-119
pubmed: 6684600
Genetics. 1991 Sep;129(1):79-94
pubmed: 1936965
Autophagy. 2010 Jul;6(5):622-33
pubmed: 20523114
Cell Death Differ. 2016 Jun;23(6):915-26
pubmed: 26990661
Dev Cell. 2014 Jan 13;28(1):43-55
pubmed: 24374177
Genetics. 1974 May;77(1):71-94
pubmed: 4366476
J Cell Biol. 2012 Apr 2;197(1):27-35
pubmed: 22451698
J Microsc. 2006 Dec;224(Pt 3):213-32
pubmed: 17210054
Infect Immun. 2012 Sep;80(9):3065-76
pubmed: 22710871
Nat Cell Biol. 2008 May;10(5):556-66
pubmed: 18425118
Mol Biol Cell. 2011 Jul 1;22(13):2290-300
pubmed: 21525242
Development. 1999 Feb;126(5):1011-22
pubmed: 9927601
Cell. 2007 Mar 9;128(5):931-46
pubmed: 17350577
Mol Biol Cell. 2011 Feb 1;22(3):354-74
pubmed: 21148288