Autonomic nervous system development and its impact on neuropsychiatric outcome.
Journal
Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
14
05
2018
accepted:
01
08
2018
revised:
27
07
2018
pubmed:
1
9
2018
medline:
3
4
2020
entrez:
1
9
2018
Statut:
ppublish
Résumé
The central autonomic nervous system (ANS) is essential for maintaining cardiovascular and respiratory homeostasis in the newborn and has a critical role in supporting higher cortical functions. At birth, the central ANS is maturing and is vulnerable to adverse environmental and physiologic influences. Critical connections are formed early in development between the ANS and limbic system to integrate psychological and body responses. The Polyvagal Theory, developed by Stephen Porges, describes how modulation of the autonomic vagal impulse controls social responses and that a broad range of neuropsychiatric disorders may be due to impaired vagal balance, with either deficient vagal tone or excessive vagal reactivity. Under additional circumstances of prematurity, growth restriction, and environmental stress in the fetus and newborn, the immature ANS may undergo "dysmaturation". Maternal stress and health as well as the intrauterine environment are also quite important and have been implicated in causing ANS changes in the infant and neuropsychiatric diseases in children. This review will cover the aspects of ANS development and maturation that have been associated with neuropsychiatric disorders in children.
Identifiants
pubmed: 30166644
doi: 10.1038/s41390-018-0155-0
pii: 10.1038/s41390-018-0155-0
pmc: PMC6353676
mid: NIHMS1503435
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
120-126Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR001877
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090257
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001876
Pays : United States
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