Effects of manipulating the interstimulus interval on heat-evoked temporal summation of second pain across the age span.
Adolescent
Adult
Aged
Aging
Analysis of Variance
Anxiety
/ etiology
Catastrophization
/ psychology
Electric Stimulation
/ adverse effects
Female
Hot Temperature
/ adverse effects
Humans
Hyperalgesia
/ physiopathology
Male
Middle Aged
Pain
/ epidemiology
Pain Measurement
Pain Threshold
/ physiology
Time Factors
Young Adult
Journal
Pain
ISSN: 1872-6623
Titre abrégé: Pain
Pays: United States
ID NLM: 7508686
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
pubmed:
1
9
2018
medline:
27
6
2019
entrez:
1
9
2018
Statut:
ppublish
Résumé
This study examined the effects of interstimulus interval (ISI) on heat-evoked temporal summation of second pain (TSSP) and tested whether greatest maintenance of TSSP would occur at longer ISIs in older adults. Several lines of evidence support that TSSP is associated with central sensitization and is centrally mediated. The participants were 198 community-dwelling adults divided into 3 age cohorts (18-39, 40-59, and 60-78 years of age). Six TSSP trials used a train of 10 contacts with a preheated probe that made repetitive contact with the volar forearm. Participants completed 2 trials at each ISI of 2.5, 3.5, and 4.5 seconds. The intraclass correlations for each pair of trials support the reliability of the current methodology. Temporal summation of second pain scores declined in a time-dependent manner across ISI. In addition, greater maintenance of TSSP at longer ISIs was observed in middle-aged and older age groups compared with the younger cohort. Significant associations were found between TSSP and measures of recent pain. Greater summation at longer ISIs in older adults would suggest slower decay of excitability in spinal neurons and infer increased risk for central sensitization with advancing age.
Identifiants
pubmed: 30169423
doi: 10.1097/j.pain.0000000000001382
pmc: PMC6357227
mid: NIHMS1005438
pii: 00006396-201901000-00013
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-101Subventions
Organisme : NIA NIH HHS
ID : K01 AG048259
Pays : United States
Organisme : NIA NIH HHS
ID : L30 AG043172
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059809
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG039659
Pays : United States
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