Kidney size in relation to ageing, gender, renal function, birthweight and chronic kidney disease risk factors in a general population.
Adolescent
Adult
Aged
Aged, 80 and over
Aging
Birth Weight
Body Mass Index
Diabetes Mellitus
/ physiopathology
Female
Humans
Kidney
/ anatomy & histology
Male
Middle Aged
Obesity
/ physiopathology
Renal Insufficiency, Chronic
/ epidemiology
Risk Factors
Sex Factors
Ultrasonography
Waist-Hip Ratio
Young Adult
age
elderly
epidemiology
gender
ultrasonography
Journal
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
ISSN: 1460-2385
Titre abrégé: Nephrol Dial Transplant
Pays: England
ID NLM: 8706402
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
19
05
2018
accepted:
18
07
2018
pubmed:
1
9
2018
medline:
27
10
2020
entrez:
1
9
2018
Statut:
ppublish
Résumé
The relationship of kidney size to ageing, kidney function and kidney disease risk factors is not fully understood. Ultrasound length and parenchymal kidney volume were determined from a population-based sample of 3972 Sardinians (age range 18-100 years). We then identified the subset of 2256 'healthy' subjects to define age- and sex-specific reference ranges (2.5-97.5 percentile) of kidney volume. Logistic regression (accounting for family clustering) was used to identify the clinical characteristics associated with abnormally large kidneys or abnormally small kidneys. In the healthy subset, kidney volume and length increased up to the fourth to fifth decade of life followed by a progressive decrease in men, whereas there was a gradual kidney volume decrease throughout the lifespan of women. In the whole sample, independent predictors of lower kidney volume (<2.5 percentile for age and sex) were male sex, low body mass index, short height, low waist:hip ratio and high serum creatinine (SCr); the independent predictors of larger kidney volume (>97.5 percentile for age and sex) were younger age, female sex, diabetes, obesity, high height, high waist:hip ratio and lower SCr. Estimated heritability for kidney volume was 15%, and for length 27%; kidney volume correlated strongly with birthweight. Overall, in a general healthy population, kidney measures declined with age differently in men and women. The determinants of kidney parenchymal volume include genetic factors and modifiable clinical factors.
Sections du résumé
BACKGROUND
The relationship of kidney size to ageing, kidney function and kidney disease risk factors is not fully understood.
METHODS
Ultrasound length and parenchymal kidney volume were determined from a population-based sample of 3972 Sardinians (age range 18-100 years). We then identified the subset of 2256 'healthy' subjects to define age- and sex-specific reference ranges (2.5-97.5 percentile) of kidney volume. Logistic regression (accounting for family clustering) was used to identify the clinical characteristics associated with abnormally large kidneys or abnormally small kidneys.
RESULTS
In the healthy subset, kidney volume and length increased up to the fourth to fifth decade of life followed by a progressive decrease in men, whereas there was a gradual kidney volume decrease throughout the lifespan of women. In the whole sample, independent predictors of lower kidney volume (<2.5 percentile for age and sex) were male sex, low body mass index, short height, low waist:hip ratio and high serum creatinine (SCr); the independent predictors of larger kidney volume (>97.5 percentile for age and sex) were younger age, female sex, diabetes, obesity, high height, high waist:hip ratio and lower SCr. Estimated heritability for kidney volume was 15%, and for length 27%; kidney volume correlated strongly with birthweight.
CONCLUSIONS
Overall, in a general healthy population, kidney measures declined with age differently in men and women. The determinants of kidney parenchymal volume include genetic factors and modifiable clinical factors.
Identifiants
pubmed: 30169833
pii: 5086498
doi: 10.1093/ndt/gfy270
pmc: PMC7139213
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
640-647Subventions
Organisme : NIDA NIH HHS
ID : HHSN271201100005C
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK090358
Pays : United States
Organisme : NIA NIH HHS
ID : N01AG12109
Pays : United States
Informations de copyright
Published by Oxford University Press on behalf of ERA-EDTA 2018. This work is written by US Government employees and is in the public domain in the US.
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