Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection.
Adult
Archaea
Bacteroides
Butyrates
/ metabolism
CD4 Lymphocyte Count
/ methods
CD4-Positive T-Lymphocytes
/ immunology
Cross-Sectional Studies
Dysbiosis
/ complications
Feces
/ chemistry
Female
Gastrointestinal Microbiome
/ immunology
HIV Infections
/ complications
HIV-1
/ physiology
Humans
Intestinal Mucosa
/ immunology
Male
Middle Aged
Prognosis
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
17
05
2018
accepted:
08
08
2018
revised:
03
08
2018
pubmed:
2
9
2018
medline:
15
5
2019
entrez:
2
9
2018
Statut:
ppublish
Résumé
Human immunodeficiency virus (HIV)-1 infection causes severe gut and systemic immune damage, but its effects on the gut microbiome remain unclear. Previous shotgun metagenomic studies in HIV-negative subjects linked low-microbial gene counts (LGC) to gut dysbiosis in diseases featuring intestinal inflammation. Using a similar approach in 156 subjects with different HIV-1 phenotypes, we found a strong, independent, dose-effect association between nadir CD4+ T-cell counts and LGC. As in other diseases involving intestinal inflammation, the gut microbiomes of subjects with LGC were enriched in gram-negative Bacteroides, acetogenic bacteria and Proteobacteria, which are able to metabolize reactive oxygen and nitrogen species; and were depleted in oxygen-sensitive methanogenic archaea and sulfate-reducing bacteria. Interestingly, subjects with LGC also showed increased butyrate levels in direct fecal measurements, consistent with enrichment in Roseburia intestinalis despite reductions in other butyrate producers. The microbiomes of subjects with LGC were also enriched in bacterial virulence factors, as well as in genes associated with beta-lactam, lincosamide, tetracycline, and macrolide resistance. Thus, low nadir CD4+ T-cell counts, rather than HIV-1 serostatus per se, predict the presence of gut dysbiosis in HIV-1 infected subjects. Such dysbiosis does not display obvious HIV-specific features; instead, it shares many similarities with other diseases featuring gut inflammation.
Identifiants
pubmed: 30171206
doi: 10.1038/s41385-018-0083-7
pii: S1933-0219(22)00370-1
doi:
Substances chimiques
Butyrates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
232-246Références
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