BMP6-induced modulation of the tumor micro-milieu.
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
09
11
2017
accepted:
27
07
2018
revised:
22
06
2018
pubmed:
2
9
2018
medline:
27
2
2019
entrez:
2
9
2018
Statut:
ppublish
Résumé
Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progression in a melanoma mouse model. Moreover, we determined that BMP6 inhibits dermal mast cell recruitment and found that mast cell-derived mediators significantly reduced melanoma growth in vitro. In line with this, mast cell deficiency accelerated tumor onset and progression in a melanoma mouse model. Analysis of human melanoma tissues revealed a strong negative correlation between melanoma proliferation and mast cell infiltration. This study elucidates a novel role of BMP6-induced modulation of the tumor microenvironment.
Identifiants
pubmed: 30171260
doi: 10.1038/s41388-018-0475-x
pii: 10.1038/s41388-018-0475-x
doi:
Substances chimiques
BMP6 protein, human
0
Bmp6 protein, mouse
0
Bone Morphogenetic Protein 6
0
Neoplasm Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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