Shear stress promotes anoikis resistance of cancer cells via caveolin-1-dependent extrinsic and intrinsic apoptotic pathways.
Anoikis
Apoptosis
Breast Neoplasms
/ genetics
Caveolin 1
/ genetics
Cell Line, Tumor
Cell Proliferation
Female
Focal Adhesion Kinase 1
/ metabolism
Gene Expression Regulation, Neoplastic
Humans
Integrin beta1
/ metabolism
Mechanotransduction, Cellular
Mitochondria
/ metabolism
Neoplastic Cells, Circulating
/ metabolism
Stress, Mechanical
fas Receptor
/ metabolism
Cav-1
Fas
anoikis resistance
breast cancer
low shear stress
mitochondria
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
07
03
2018
accepted:
05
07
2018
pubmed:
2
9
2018
medline:
17
3
2020
entrez:
2
9
2018
Statut:
ppublish
Résumé
Circulating tumor cells (CTCs) need to acquire resistance to anoikis to survive after they experience fluid shear stress in the circulatory and lymphatic systems. However, the mechanism by which tumor cells resist anoikis under shear stress conditions remains unknown. Here, we found that the application of low shear stress (LSS; 2 dyn/cm
Substances chimiques
CAV1 protein, human
0
Caveolin 1
0
FAS protein, human
0
Integrin beta1
0
fas Receptor
0
Focal Adhesion Kinase 1
EC 2.7.10.2
PTK2 protein, human
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3730-3743Informations de copyright
© 2018 Wiley Periodicals, Inc.