Modulating transcription factor activity: Interfering with protein-protein interaction networks.
Developmental biology
Drug development
Network
Protein-protein interactions
Redundancy
Small compounds
Transcription factor
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
04
11
2017
revised:
16
02
2018
accepted:
17
07
2018
pubmed:
3
9
2018
medline:
12
3
2021
entrez:
3
9
2018
Statut:
ppublish
Résumé
Biophysical parameters that govern transcription factors activity are binding locations across the genome, dwelling time at these regulatory elements and specific protein-protein interactions. Most molecular strategies used to develop small compounds that block transcription factors activity have been based on biochemistry and cell biology methods that that do not take into consideration these key biophysical features. Here, we review the advance in the field of transcription factor biology and describe how their interactome and transcriptional regulation on a genome wide scale have been deciphered. We suggest that this new knowledge has the potential to be used to implement innovative research drug discovery program.
Identifiants
pubmed: 30172762
pii: S1084-9521(17)30547-5
doi: 10.1016/j.semcdb.2018.07.019
pii:
doi:
Substances chimiques
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
12-19Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.